Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.

Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.

Class switch DNA recombination (CSR) of the immunoglobulin heavy chain (IgH) locus crucially diversifies antibody biological effector functions. CSR involves the induction of activation-induced cytidine deaminase (AID) expression and AID targeting to switch (S) regions by 14-3-3 adaptors. 14-3-3 ada...

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Autores principales: Tonika Lam, Lisa M Thomas, Clayton A White, Guideng Li, Egest J Pone, Zhenming Xu, Paolo Casali
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b3caa5d832f34c3da8f1f39c33e0ebbc
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