Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox

Izumi Mine, Sho Ishikawa, Masaru TakeuchiDepartment of Ophthalmology, National Defense Medical College, Tokorozawa City, Saitama, JapanAim: The aim of this report was to present a case of varicella zoster virus (VZV)-associated anterior uveitis, which developed in an adult who was seronegative for...

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Autores principales:	Mine I, Ishikawa S, Takeuchi M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b3ce5dee3db645929a47524e582eafe8
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spelling	oai:doaj.org-article:b3ce5dee3db645929a47524e582eafe82021-12-02T08:05:02ZVaricella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox1177-5483https://doaj.org/article/b3ce5dee3db645929a47524e582eafe82015-02-01T00:00:00Zhttp://www.dovepress.com/varicella-zoster-virus-associated-anterior-uveitis-in-a-seronegative-a-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Izumi Mine, Sho Ishikawa, Masaru TakeuchiDepartment of Ophthalmology, National Defense Medical College, Tokorozawa City, Saitama, JapanAim: The aim of this report was to present a case of varicella zoster virus (VZV)-associated anterior uveitis, which developed in an adult who was seronegative for anti-VZV antibodies.Case presentation: A 66-year-old male patient was referred to the National Defense Medical College, Tokorozawa City, Japan with iridocyclitis in his right eye. On examination, intraocular pressure was 30 mmHg in the right eye, and biomicroscopy revealed ciliary injection, corneal epithelial edema, mutton fat keratic precipitates, flare, and infiltrating cells in the anterior chamber. Serological tests were negative for anti-VZV antibodies, but VZV-DNA copies of 1.28×107 copies/mL were detected by quantitative reverse transcriptase polymerase chain reaction using the aqueous humor obtained from the right eye. Iridocyclitis was reduced by administration of oral valaciclovir in addition to corticosteroid eye drops, and serum anti-VZV antibodies were first detected after 4 months’ administration. When ocular inflammation was resolved after 6 months, VZV-DNA could not be detected in the aqueous humor any more.Conclusion: VZV-associated uveitis may develop in an adult with undetectable serum anti-VZV antibodies. Multiplex polymerase chain reaction of the aqueous humor is the key investigation necessary for the diagnosis in such cases.Keywords: varicella zoster virus, VZV, zoster sine herpete, multiplex polymerase chain reaction, uveitic glaucomaMine IIshikawa STakeuchi MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 399-402 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mine I Ishikawa S Takeuchi M Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox
description	Izumi Mine, Sho Ishikawa, Masaru TakeuchiDepartment of Ophthalmology, National Defense Medical College, Tokorozawa City, Saitama, JapanAim: The aim of this report was to present a case of varicella zoster virus (VZV)-associated anterior uveitis, which developed in an adult who was seronegative for anti-VZV antibodies.Case presentation: A 66-year-old male patient was referred to the National Defense Medical College, Tokorozawa City, Japan with iridocyclitis in his right eye. On examination, intraocular pressure was 30 mmHg in the right eye, and biomicroscopy revealed ciliary injection, corneal epithelial edema, mutton fat keratic precipitates, flare, and infiltrating cells in the anterior chamber. Serological tests were negative for anti-VZV antibodies, but VZV-DNA copies of 1.28×107 copies/mL were detected by quantitative reverse transcriptase polymerase chain reaction using the aqueous humor obtained from the right eye. Iridocyclitis was reduced by administration of oral valaciclovir in addition to corticosteroid eye drops, and serum anti-VZV antibodies were first detected after 4 months’ administration. When ocular inflammation was resolved after 6 months, VZV-DNA could not be detected in the aqueous humor any more.Conclusion: VZV-associated uveitis may develop in an adult with undetectable serum anti-VZV antibodies. Multiplex polymerase chain reaction of the aqueous humor is the key investigation necessary for the diagnosis in such cases.Keywords: varicella zoster virus, VZV, zoster sine herpete, multiplex polymerase chain reaction, uveitic glaucoma
format	article
author	Mine I Ishikawa S Takeuchi M
author_facet	Mine I Ishikawa S Takeuchi M
author_sort	Mine I
title	Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox
title_short	Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox
title_full	Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox
title_fullStr	Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox
title_full_unstemmed	Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox
title_sort	varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b3ce5dee3db645929a47524e582eafe8
work_keys_str_mv	AT minei varicellazostervirusassociatedanterioruveitisinaseronegativeadultwithoutahistoryofchickenpox AT ishikawas varicellazostervirusassociatedanterioruveitisinaseronegativeadultwithoutahistoryofchickenpox AT takeuchim varicellazostervirusassociatedanterioruveitisinaseronegativeadultwithoutahistoryofchickenpox
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Varicella zoster virus-associated anterior uveitis in a seronegative adult without a history of chickenpox

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