Elongator and codon bias regulate protein levels in mammalian peripheral neurons

Familial dysautonomia is linked to mutations in IKBKAP, a scaffolding protein for the Elongator complex, which regulates codon-biased gene translation in yeast. Here the authors show in mammalian neurons that IKBKAP loss alters expression of codon-biased genes, including some involved in DNA damage.

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Autores principales:	Joy Goffena, Frances Lefcort, Yongqing Zhang, Elin Lehrmann, Marta Chaverra, Jehremy Felig, Joseph Walters, Richard Buksch, Kevin G. Becker, Lynn George
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3d0607b35bc41de8e95899931217012
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spelling	oai:doaj.org-article:b3d0607b35bc41de8e958999312170122021-12-02T17:31:27ZElongator and codon bias regulate protein levels in mammalian peripheral neurons10.1038/s41467-018-03221-z2041-1723https://doaj.org/article/b3d0607b35bc41de8e958999312170122018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03221-zhttps://doaj.org/toc/2041-1723Familial dysautonomia is linked to mutations in IKBKAP, a scaffolding protein for the Elongator complex, which regulates codon-biased gene translation in yeast. Here the authors show in mammalian neurons that IKBKAP loss alters expression of codon-biased genes, including some involved in DNA damage.Joy GoffenaFrances LefcortYongqing ZhangElin LehrmannMarta ChaverraJehremy FeligJoseph WaltersRichard BukschKevin G. BeckerLynn GeorgeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joy Goffena Frances Lefcort Yongqing Zhang Elin Lehrmann Marta Chaverra Jehremy Felig Joseph Walters Richard Buksch Kevin G. Becker Lynn George Elongator and codon bias regulate protein levels in mammalian peripheral neurons
description	Familial dysautonomia is linked to mutations in IKBKAP, a scaffolding protein for the Elongator complex, which regulates codon-biased gene translation in yeast. Here the authors show in mammalian neurons that IKBKAP loss alters expression of codon-biased genes, including some involved in DNA damage.
format	article
author	Joy Goffena Frances Lefcort Yongqing Zhang Elin Lehrmann Marta Chaverra Jehremy Felig Joseph Walters Richard Buksch Kevin G. Becker Lynn George
author_facet	Joy Goffena Frances Lefcort Yongqing Zhang Elin Lehrmann Marta Chaverra Jehremy Felig Joseph Walters Richard Buksch Kevin G. Becker Lynn George
author_sort	Joy Goffena
title	Elongator and codon bias regulate protein levels in mammalian peripheral neurons
title_short	Elongator and codon bias regulate protein levels in mammalian peripheral neurons
title_full	Elongator and codon bias regulate protein levels in mammalian peripheral neurons
title_fullStr	Elongator and codon bias regulate protein levels in mammalian peripheral neurons
title_full_unstemmed	Elongator and codon bias regulate protein levels in mammalian peripheral neurons
title_sort	elongator and codon bias regulate protein levels in mammalian peripheral neurons
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b3d0607b35bc41de8e95899931217012
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Elongator and codon bias regulate protein levels in mammalian peripheral neurons

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