Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules

Abstract Multifocal micronodular pneumocyte hyperplasia (MMPH) is the lesser known pulmonary manifestation of tuberous sclerosis. It manifests radiologically as diffuse small ground‐glass and solid nodules. Accurate diagnosis is essential as it can be mistaken for miliary tuberculosis or malignant l...

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Autores principales:	Li Yan Sandra Hui, Xin Min Cheng, Ing Xiang Soo, Su Ying Low
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cystic lung disease lung nodules lymphangioleiomyomatosis multifocal micronodular pneumocyte hyperplasia tuberous sclerosis complex Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/b3d1233ffcf2454892b811ded6386e38
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spelling	oai:doaj.org-article:b3d1233ffcf2454892b811ded6386e382021-11-25T13:46:30ZRecurrent pneumothoraces with diffuse small ground‐glass and solid nodules2051-338010.1002/rcr2.870https://doaj.org/article/b3d1233ffcf2454892b811ded6386e382021-12-01T00:00:00Zhttps://doi.org/10.1002/rcr2.870https://doaj.org/toc/2051-3380Abstract Multifocal micronodular pneumocyte hyperplasia (MMPH) is the lesser known pulmonary manifestation of tuberous sclerosis. It manifests radiologically as diffuse small ground‐glass and solid nodules. Accurate diagnosis is essential as it can be mistaken for miliary tuberculosis or malignant lesions which necessitates specific treatment. Constellation of radiological features such as multicentric disease at onset and stability over time can help to distinguish MMPH from its differentials. Histologically, MMPH is characterized by hamartomatous proliferation of type II pneumocytes with a lack of high nuclear to cytoplasmic ratio. MMPH confers a benign prognosis unlike its differentials. Therefore, accurate diagnosis is paramount in ensuring appropriate care is delivered. Here, we describe the radiological and histological features of MMPH in a patient with genetically proven tuberous sclerosis complex and co‐existing lymphangioleiomyomatosis.Li Yan Sandra HuiXin Min ChengIng Xiang SooSu Ying LowWileyarticlecystic lung diseaselung noduleslymphangioleiomyomatosismultifocal micronodular pneumocyte hyperplasiatuberous sclerosis complexDiseases of the respiratory systemRC705-779ENRespirology Case Reports, Vol 9, Iss 12, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystic lung disease lung nodules lymphangioleiomyomatosis multifocal micronodular pneumocyte hyperplasia tuberous sclerosis complex Diseases of the respiratory system RC705-779
spellingShingle	cystic lung disease lung nodules lymphangioleiomyomatosis multifocal micronodular pneumocyte hyperplasia tuberous sclerosis complex Diseases of the respiratory system RC705-779 Li Yan Sandra Hui Xin Min Cheng Ing Xiang Soo Su Ying Low Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules
description	Abstract Multifocal micronodular pneumocyte hyperplasia (MMPH) is the lesser known pulmonary manifestation of tuberous sclerosis. It manifests radiologically as diffuse small ground‐glass and solid nodules. Accurate diagnosis is essential as it can be mistaken for miliary tuberculosis or malignant lesions which necessitates specific treatment. Constellation of radiological features such as multicentric disease at onset and stability over time can help to distinguish MMPH from its differentials. Histologically, MMPH is characterized by hamartomatous proliferation of type II pneumocytes with a lack of high nuclear to cytoplasmic ratio. MMPH confers a benign prognosis unlike its differentials. Therefore, accurate diagnosis is paramount in ensuring appropriate care is delivered. Here, we describe the radiological and histological features of MMPH in a patient with genetically proven tuberous sclerosis complex and co‐existing lymphangioleiomyomatosis.
format	article
author	Li Yan Sandra Hui Xin Min Cheng Ing Xiang Soo Su Ying Low
author_facet	Li Yan Sandra Hui Xin Min Cheng Ing Xiang Soo Su Ying Low
author_sort	Li Yan Sandra Hui
title	Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules
title_short	Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules
title_full	Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules
title_fullStr	Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules
title_full_unstemmed	Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules
title_sort	recurrent pneumothoraces with diffuse small ground‐glass and solid nodules
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/b3d1233ffcf2454892b811ded6386e38
work_keys_str_mv	AT liyansandrahui recurrentpneumothoraceswithdiffusesmallgroundglassandsolidnodules AT xinmincheng recurrentpneumothoraceswithdiffusesmallgroundglassandsolidnodules AT ingxiangsoo recurrentpneumothoraceswithdiffusesmallgroundglassandsolidnodules AT suyinglow recurrentpneumothoraceswithdiffusesmallgroundglassandsolidnodules
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Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules

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