Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis

BACKGROUND: Human parvovirus B19 (B19V) is one of the blood-borne viruses. The virus can be transmitted to susceptible individuals by blood or blood products. The virus is not associated with significant disease in general population, while people with underlying problems such as immunodeficiency ca...

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Autores principales:	Mohammad Farahmand, Ahmad Tavakoli, Saied Ghorbani, Seyed Hamidreza Monavari, Seyed Jalal Kiani, Sara Minaeian
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	b19v dna blood donors meta-analysis parvovirus b19 seroprevalence Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/b3d4f3f242c742f095f49138ce628428
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spelling	oai:doaj.org-article:b3d4f3f242c742f095f49138ce6284282021-11-12T10:08:28ZMolecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis0973-62471998-356510.4103/ajts.ajts_185_20https://doaj.org/article/b3d4f3f242c742f095f49138ce6284282021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=212;epage=222;aulast=Farahmandhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565BACKGROUND: Human parvovirus B19 (B19V) is one of the blood-borne viruses. The virus can be transmitted to susceptible individuals by blood or blood products. The virus is not associated with significant disease in general population, while people with underlying problems such as immunodeficiency can cause anemia and arthritis. The current systematic review and meta-analysis aimed to estimate the overall prevalence of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies in blood donors worldwide.METHODS: A systematic search was carried out in online databases for relevant studies from inception until March 30, 2019. Study selection was performed based on predesigned eligibility criteria. The proportion of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies were pooled using the inverse variance method. All statistical analyses were performed using the R version 3.5.3, package “meta.”RESULTS: According to the random-effects model, the pool prevalence of B19V DNA, anti-B19V IgM, and anti-B19V IgG among blood donors was calculated to be 0.4% (95% confidence interval [CI] =0.3%–0.6%), 2.2% (95% CI = 1.3%–3.7%), and 50.1% (95% CI = 43.1%–57.1%), respectively.CONCLUSION: For the transmission of B19V through blood, the presence of the virus genome is required, and the present study showed that the prevalence of the virus genome in blood donors is <1%. Therefore, there is no need to screen donated blood for B19V infection.Mohammad FarahmandAhmad TavakoliSaied GhorbaniSeyed Hamidreza MonavariSeyed Jalal KianiSara MinaeianWolters Kluwer Medknow Publicationsarticleb19v dnablood donorsmeta-analysisparvovirus b19seroprevalenceDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 212-222 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	b19v dna blood donors meta-analysis parvovirus b19 seroprevalence Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	b19v dna blood donors meta-analysis parvovirus b19 seroprevalence Diseases of the blood and blood-forming organs RC633-647.5 Mohammad Farahmand Ahmad Tavakoli Saied Ghorbani Seyed Hamidreza Monavari Seyed Jalal Kiani Sara Minaeian Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis
description	BACKGROUND: Human parvovirus B19 (B19V) is one of the blood-borne viruses. The virus can be transmitted to susceptible individuals by blood or blood products. The virus is not associated with significant disease in general population, while people with underlying problems such as immunodeficiency can cause anemia and arthritis. The current systematic review and meta-analysis aimed to estimate the overall prevalence of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies in blood donors worldwide.METHODS: A systematic search was carried out in online databases for relevant studies from inception until March 30, 2019. Study selection was performed based on predesigned eligibility criteria. The proportion of B19V DNA, anti-B19V IgG, and anti-B19V IgM antibodies were pooled using the inverse variance method. All statistical analyses were performed using the R version 3.5.3, package “meta.”RESULTS: According to the random-effects model, the pool prevalence of B19V DNA, anti-B19V IgM, and anti-B19V IgG among blood donors was calculated to be 0.4% (95% confidence interval [CI] =0.3%–0.6%), 2.2% (95% CI = 1.3%–3.7%), and 50.1% (95% CI = 43.1%–57.1%), respectively.CONCLUSION: For the transmission of B19V through blood, the presence of the virus genome is required, and the present study showed that the prevalence of the virus genome in blood donors is <1%. Therefore, there is no need to screen donated blood for B19V infection.
format	article
author	Mohammad Farahmand Ahmad Tavakoli Saied Ghorbani Seyed Hamidreza Monavari Seyed Jalal Kiani Sara Minaeian
author_facet	Mohammad Farahmand Ahmad Tavakoli Saied Ghorbani Seyed Hamidreza Monavari Seyed Jalal Kiani Sara Minaeian
author_sort	Mohammad Farahmand
title	Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis
title_short	Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis
title_full	Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis
title_fullStr	Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis
title_full_unstemmed	Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis
title_sort	molecular and serological markers of human parvovirus b19 infection in blood donors: a systematic review and meta-analysis
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/b3d4f3f242c742f095f49138ce628428
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Molecular and serological markers of human parvovirus B19 infection in blood donors: A systematic review and meta-analysis

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