Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells

Abstract Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment...

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Autores principales:	Alan Morettin, Geneviève Paris, Younes Bouzid, R. Mitchell Baldwin, Theresa J. Falls, John C. Bell, Jocelyn Côté
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3d5a9fb36324400b4cbf9271ff6ea12
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spelling	oai:doaj.org-article:b3d5a9fb36324400b4cbf9271ff6ea122021-12-02T11:52:23ZTudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells10.1038/s41598-017-04955-42045-2322https://doaj.org/article/b3d5a9fb36324400b4cbf9271ff6ea122017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04955-4https://doaj.org/toc/2045-2322Abstract Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs in cancer cells. Here, we report TDRD3 as a novel regulator of cell proliferation and invasion in breast cancer cells. Our study also demonstrates that TDRD3 depletion inhibits tumor formation and metastasis to the lung in vivo. Furthermore, we show that TDRD3 regulates the expression of a number of key genes associated with promotion of breast cancer tumorigenesis and disease progression. Strikingly, we report that TDRD3 regulates some of these key targets at the level of translation. These findings provide the first experimental demonstration of a functional role for TDRD3 in promoting breast cancer development and progression, and identify TDRD3 as a potential new therapeutic target for breast cancer.Alan MorettinGeneviève ParisYounes BouzidR. Mitchell BaldwinTheresa J. FallsJohn C. BellJocelyn CôtéNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alan Morettin Geneviève Paris Younes Bouzid R. Mitchell Baldwin Theresa J. Falls John C. Bell Jocelyn Côté Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells
description	Abstract Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs in cancer cells. Here, we report TDRD3 as a novel regulator of cell proliferation and invasion in breast cancer cells. Our study also demonstrates that TDRD3 depletion inhibits tumor formation and metastasis to the lung in vivo. Furthermore, we show that TDRD3 regulates the expression of a number of key genes associated with promotion of breast cancer tumorigenesis and disease progression. Strikingly, we report that TDRD3 regulates some of these key targets at the level of translation. These findings provide the first experimental demonstration of a functional role for TDRD3 in promoting breast cancer development and progression, and identify TDRD3 as a potential new therapeutic target for breast cancer.
format	article
author	Alan Morettin Geneviève Paris Younes Bouzid R. Mitchell Baldwin Theresa J. Falls John C. Bell Jocelyn Côté
author_facet	Alan Morettin Geneviève Paris Younes Bouzid R. Mitchell Baldwin Theresa J. Falls John C. Bell Jocelyn Côté
author_sort	Alan Morettin
title	Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells
title_short	Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells
title_full	Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells
title_fullStr	Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells
title_full_unstemmed	Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells
title_sort	tudor domain containing protein 3 promotes tumorigenesis and invasive capacity of breast cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b3d5a9fb36324400b4cbf9271ff6ea12
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Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells

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