Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
Kim Valette et al. perform a genomic study on asthma integrating genome-wide association study, functional mapping using lung and blood transcriptome-wide profiles, as well as Mendelian randomization. They show candidate causal genes expressed in lung and blood tissues that are putative therapeutic...
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Nature Portfolio
2021
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oai:doaj.org-article:b3d76be062194736bdde905088a0270a2021-12-02T17:52:40ZPrioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank10.1038/s42003-021-02227-62399-3642https://doaj.org/article/b3d76be062194736bdde905088a0270a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02227-6https://doaj.org/toc/2399-3642Kim Valette et al. perform a genomic study on asthma integrating genome-wide association study, functional mapping using lung and blood transcriptome-wide profiles, as well as Mendelian randomization. They show candidate causal genes expressed in lung and blood tissues that are putative therapeutic targets for asthma.Kim ValetteZhonglin LiValentin Bon-BaretArnaud ChignonJean-Christophe BérubéAida EslamiJennifer LamotheNathalie GaudreaultPhilippe JoubertMa’en ObeidatMaarten van den BergeWim TimensDon D. SinDavid C. NickleKe HaoCatherine LabbéKrystelle GodboutAndréanne CôtéMichel LavioletteLouis-Philippe BouletPatrick MathieuSébastien ThériaultYohan BosséNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Kim Valette Zhonglin Li Valentin Bon-Baret Arnaud Chignon Jean-Christophe Bérubé Aida Eslami Jennifer Lamothe Nathalie Gaudreault Philippe Joubert Ma’en Obeidat Maarten van den Berge Wim Timens Don D. Sin David C. Nickle Ke Hao Catherine Labbé Krystelle Godbout Andréanne Côté Michel Laviolette Louis-Philippe Boulet Patrick Mathieu Sébastien Thériault Yohan Bossé Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank |
| description |
Kim Valette et al. perform a genomic study on asthma integrating genome-wide association study, functional mapping using lung and blood transcriptome-wide profiles, as well as Mendelian randomization. They show candidate causal genes expressed in lung and blood tissues that are putative therapeutic targets for asthma. |
| format |
article |
| author |
Kim Valette Zhonglin Li Valentin Bon-Baret Arnaud Chignon Jean-Christophe Bérubé Aida Eslami Jennifer Lamothe Nathalie Gaudreault Philippe Joubert Ma’en Obeidat Maarten van den Berge Wim Timens Don D. Sin David C. Nickle Ke Hao Catherine Labbé Krystelle Godbout Andréanne Côté Michel Laviolette Louis-Philippe Boulet Patrick Mathieu Sébastien Thériault Yohan Bossé |
| author_facet |
Kim Valette Zhonglin Li Valentin Bon-Baret Arnaud Chignon Jean-Christophe Bérubé Aida Eslami Jennifer Lamothe Nathalie Gaudreault Philippe Joubert Ma’en Obeidat Maarten van den Berge Wim Timens Don D. Sin David C. Nickle Ke Hao Catherine Labbé Krystelle Godbout Andréanne Côté Michel Laviolette Louis-Philippe Boulet Patrick Mathieu Sébastien Thériault Yohan Bossé |
| author_sort |
Kim Valette |
| title |
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank |
| title_short |
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank |
| title_full |
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank |
| title_fullStr |
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank |
| title_full_unstemmed |
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank |
| title_sort |
prioritization of candidate causal genes for asthma in susceptibility loci derived from uk biobank |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b3d76be062194736bdde905088a0270a |
| work_keys_str_mv |
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