Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study

BackgroundThe causal association between coffee consumption and the risk of OA is limited. This study was conducted to identify the potential causal effects of coffee consumption on total, knee, hip, and self-reported OA.MethodsGenome-wide association studies (GWAS) of OA were derived from the UK Bi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yangchang Zhang, Jun Fan, Li Chen, Yang Xiong, Tingting Wu, Shisi Shen, Xu Wang, Xuchen Meng, Yanjun Lu, Xun Lei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	coffee consumption osteoarthritis SNP Mendelian randomization Kenn hip Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/b3d776375a45464d86835d9bbd3b3e79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b3d776375a45464d86835d9bbd3b3e79
record_format	dspace
spelling	oai:doaj.org-article:b3d776375a45464d86835d9bbd3b3e792021-11-10T06:52:28ZCausal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study1664-239210.3389/fendo.2021.768529https://doaj.org/article/b3d776375a45464d86835d9bbd3b3e792021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.768529/fullhttps://doaj.org/toc/1664-2392BackgroundThe causal association between coffee consumption and the risk of OA is limited. This study was conducted to identify the potential causal effects of coffee consumption on total, knee, hip, and self-reported OA.MethodsGenome-wide association studies (GWAS) of OA were derived from the UK Biobank, comprising 50,508 participants of European ancestry (10,083 with cases and 40,425 controls), and genetic data for specific diagnosed knee OA (4462 cases and 17,885 controls), hip OA (12,625 cases and 50,898 controls), and self-reported OA (12,658 cases and 50,898 controls). Primary and secondary genetic instruments (11 SNPs and 8 SNPs) were selected as instrumental variants from GWAS among 375,833 and 91,462 participants. Two-sample Mendelian randomization (MR) analyses were performed to test the effects of the selected single nucleotide polymorphisms (SNPs) and the OA risk. The causal effects were primarily estimated using weighted median and inverse-variance weighted method with several sensitivity analyses.ResultsThe MR analyses suggested that genetically predicted 1% increase of coffee consumption was associated with an increased risk of overall OA (OR:1.009, 95% CI:1.003-1.016), knee OA (OR:1.023, 95% CI:1.009-1.038), self-reported OA (OR:1.007, 95% CI:1.003-1.011), but not hip OA (OR: 1.012, 95%CI:0.999-1.024) using primary genetic instruments. Similar results were found when using secondary genetic instruments that genetically predicted coffee consumption (cups/day). Additionally, the sensitivity analyses for leave-one-out methods supported a robust association between exposure traits and OA.ConclusionOur findings indicate that genetically predicted coffee consumption exerts a causal effect on total, knee, and self-reported OA risk, but not at the hip. Further research is required to unravel the role of coffee consumption in OA prevention.Yangchang ZhangYangchang ZhangYangchang ZhangJun FanLi ChenYang XiongTingting WuShisi ShenXu WangXu WangXu WangXuchen MengYanjun LuXun LeiXun LeiXun LeiFrontiers Media S.A.articlecoffee consumptionosteoarthritisSNPMendelian randomizationKennhipDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coffee consumption osteoarthritis SNP Mendelian randomization Kenn hip Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	coffee consumption osteoarthritis SNP Mendelian randomization Kenn hip Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yangchang Zhang Yangchang Zhang Yangchang Zhang Jun Fan Li Chen Yang Xiong Tingting Wu Shisi Shen Xu Wang Xu Wang Xu Wang Xuchen Meng Yanjun Lu Xun Lei Xun Lei Xun Lei Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study
description	BackgroundThe causal association between coffee consumption and the risk of OA is limited. This study was conducted to identify the potential causal effects of coffee consumption on total, knee, hip, and self-reported OA.MethodsGenome-wide association studies (GWAS) of OA were derived from the UK Biobank, comprising 50,508 participants of European ancestry (10,083 with cases and 40,425 controls), and genetic data for specific diagnosed knee OA (4462 cases and 17,885 controls), hip OA (12,625 cases and 50,898 controls), and self-reported OA (12,658 cases and 50,898 controls). Primary and secondary genetic instruments (11 SNPs and 8 SNPs) were selected as instrumental variants from GWAS among 375,833 and 91,462 participants. Two-sample Mendelian randomization (MR) analyses were performed to test the effects of the selected single nucleotide polymorphisms (SNPs) and the OA risk. The causal effects were primarily estimated using weighted median and inverse-variance weighted method with several sensitivity analyses.ResultsThe MR analyses suggested that genetically predicted 1% increase of coffee consumption was associated with an increased risk of overall OA (OR:1.009, 95% CI:1.003-1.016), knee OA (OR:1.023, 95% CI:1.009-1.038), self-reported OA (OR:1.007, 95% CI:1.003-1.011), but not hip OA (OR: 1.012, 95%CI:0.999-1.024) using primary genetic instruments. Similar results were found when using secondary genetic instruments that genetically predicted coffee consumption (cups/day). Additionally, the sensitivity analyses for leave-one-out methods supported a robust association between exposure traits and OA.ConclusionOur findings indicate that genetically predicted coffee consumption exerts a causal effect on total, knee, and self-reported OA risk, but not at the hip. Further research is required to unravel the role of coffee consumption in OA prevention.
format	article
author	Yangchang Zhang Yangchang Zhang Yangchang Zhang Jun Fan Li Chen Yang Xiong Tingting Wu Shisi Shen Xu Wang Xu Wang Xu Wang Xuchen Meng Yanjun Lu Xun Lei Xun Lei Xun Lei
author_facet	Yangchang Zhang Yangchang Zhang Yangchang Zhang Jun Fan Li Chen Yang Xiong Tingting Wu Shisi Shen Xu Wang Xu Wang Xu Wang Xuchen Meng Yanjun Lu Xun Lei Xun Lei Xun Lei
author_sort	Yangchang Zhang
title	Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study
title_short	Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study
title_full	Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study
title_fullStr	Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study
title_full_unstemmed	Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study
title_sort	causal association of coffee consumption and total, knee, hip and self-reported osteoarthritis: a mendelian randomization study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b3d776375a45464d86835d9bbd3b3e79
work_keys_str_mv	AT yangchangzhang causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT yangchangzhang causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT yangchangzhang causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT junfan causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT lichen causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT yangxiong causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT tingtingwu causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT shisishen causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT xuwang causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT xuwang causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT xuwang causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT xuchenmeng causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT yanjunlu causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT xunlei causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT xunlei causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy AT xunlei causalassociationofcoffeeconsumptionandtotalkneehipandselfreportedosteoarthritisamendelianrandomizationstudy
_version_	1718440499723894784

Causal Association of Coffee Consumption and Total, Knee, Hip and Self-Reported Osteoarthritis: A Mendelian Randomization Study

Ejemplares similares