Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

While reversal of lysine methylation on histone tails is a well-established mechanism to tune gene expression, the existence of a similar arginine demethylation process is controversial. Here, the authors show that some jumonji enzymes possess both lysine and arginine demethylase activity in vitro.

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Auteurs principaux: Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Rachel Schiller, Wei Ge, Akane Kawamura, Christopher J. Schofield
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/b3dc6971dc6349f5a32b481bb23ad534
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spelling oai:doaj.org-article:b3dc6971dc6349f5a32b481bb23ad5342021-12-02T15:34:10ZArginine demethylation is catalysed by a subset of JmjC histone lysine demethylases10.1038/ncomms119742041-1723https://doaj.org/article/b3dc6971dc6349f5a32b481bb23ad5342016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11974https://doaj.org/toc/2041-1723While reversal of lysine methylation on histone tails is a well-established mechanism to tune gene expression, the existence of a similar arginine demethylation process is controversial. Here, the authors show that some jumonji enzymes possess both lysine and arginine demethylase activity in vitro.Louise J. WalportRichard J. HopkinsonRasheduzzaman ChowdhuryRachel SchillerWei GeAkane KawamuraChristopher J. SchofieldNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Louise J. Walport
Richard J. Hopkinson
Rasheduzzaman Chowdhury
Rachel Schiller
Wei Ge
Akane Kawamura
Christopher J. Schofield
Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
description While reversal of lysine methylation on histone tails is a well-established mechanism to tune gene expression, the existence of a similar arginine demethylation process is controversial. Here, the authors show that some jumonji enzymes possess both lysine and arginine demethylase activity in vitro.
format article
author Louise J. Walport
Richard J. Hopkinson
Rasheduzzaman Chowdhury
Rachel Schiller
Wei Ge
Akane Kawamura
Christopher J. Schofield
author_facet Louise J. Walport
Richard J. Hopkinson
Rasheduzzaman Chowdhury
Rachel Schiller
Wei Ge
Akane Kawamura
Christopher J. Schofield
author_sort Louise J. Walport
title Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
title_short Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
title_full Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
title_fullStr Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
title_full_unstemmed Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
title_sort arginine demethylation is catalysed by a subset of jmjc histone lysine demethylases
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/b3dc6971dc6349f5a32b481bb23ad534
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