Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes

Abstract High-charge, high-energy ion particle (HZE) radiations are extraterrestrial in origin and characterized by high linear energy transfer (high-LET), which causes more severe cell damage than low-LET radiations like γ-rays or photons. High-LET radiation poses potential cancer risks for astrona...

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Autores principales:	Liang-Hao Ding, Yongjia Yu, Elijah F. Edmondson, Michael. M. Weil, Laurentiu M. Pop, Maureen McCarthy, Robert L. Ullrich, Michael D. Story
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3dce54f0f2d4be693fbecfe76062e1b
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spelling	oai:doaj.org-article:b3dce54f0f2d4be693fbecfe76062e1b2021-12-02T15:23:16ZTranscriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes10.1038/s41598-021-93467-32045-2322https://doaj.org/article/b3dce54f0f2d4be693fbecfe76062e1b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93467-3https://doaj.org/toc/2045-2322Abstract High-charge, high-energy ion particle (HZE) radiations are extraterrestrial in origin and characterized by high linear energy transfer (high-LET), which causes more severe cell damage than low-LET radiations like γ-rays or photons. High-LET radiation poses potential cancer risks for astronauts on deep space missions, but the studies of its carcinogenic effects have relied heavily on animal models. It remains uncertain whether such data are applicable to human disease. Here, we used genomics approaches to directly compare high-LET radiation-induced, low-LET radiation-induced and spontaneous hepatocellular carcinoma (HCC) in mice with a human HCC cohort from The Cancer Genome Atlas (TCGA). We identified common molecular pathways between mouse and human HCC and discovered a subset of orthologous genes (mR-HCC) that associated high-LET radiation-induced mouse HCC with a subgroup (mrHCC2) of the TCGA cohort. The mrHCC2 TCGA cohort was more enriched with tumor-suppressing immune cells and showed a better prognostic outcome than other patient subgroups.Liang-Hao DingYongjia YuElijah F. EdmondsonMichael. M. WeilLaurentiu M. PopMaureen McCarthyRobert L. UllrichMichael D. StoryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang-Hao Ding Yongjia Yu Elijah F. Edmondson Michael. M. Weil Laurentiu M. Pop Maureen McCarthy Robert L. Ullrich Michael D. Story Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes
description	Abstract High-charge, high-energy ion particle (HZE) radiations are extraterrestrial in origin and characterized by high linear energy transfer (high-LET), which causes more severe cell damage than low-LET radiations like γ-rays or photons. High-LET radiation poses potential cancer risks for astronauts on deep space missions, but the studies of its carcinogenic effects have relied heavily on animal models. It remains uncertain whether such data are applicable to human disease. Here, we used genomics approaches to directly compare high-LET radiation-induced, low-LET radiation-induced and spontaneous hepatocellular carcinoma (HCC) in mice with a human HCC cohort from The Cancer Genome Atlas (TCGA). We identified common molecular pathways between mouse and human HCC and discovered a subset of orthologous genes (mR-HCC) that associated high-LET radiation-induced mouse HCC with a subgroup (mrHCC2) of the TCGA cohort. The mrHCC2 TCGA cohort was more enriched with tumor-suppressing immune cells and showed a better prognostic outcome than other patient subgroups.
format	article
author	Liang-Hao Ding Yongjia Yu Elijah F. Edmondson Michael. M. Weil Laurentiu M. Pop Maureen McCarthy Robert L. Ullrich Michael D. Story
author_facet	Liang-Hao Ding Yongjia Yu Elijah F. Edmondson Michael. M. Weil Laurentiu M. Pop Maureen McCarthy Robert L. Ullrich Michael D. Story
author_sort	Liang-Hao Ding
title	Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes
title_short	Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes
title_full	Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes
title_fullStr	Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes
title_full_unstemmed	Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes
title_sort	transcriptomic analysis links hepatocellular carcinoma (hcc) in hze ion irradiated mice to a human hcc subtype with favorable outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3dce54f0f2d4be693fbecfe76062e1b
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Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes

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