DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement

Heavy atom nanoparticles, such as gold nanoparticles, are proven effective radiosensitizers in radiotherapy to enhance the dose delivery for cancer treatment. This study investigated the effectiveness of cancer cell killing, involving gold nanoparticle in proton radiation, by changing the nanopartic...

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Autores principales:	Ngoc Han Huynh, James C. L. Chow
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	radiosensitizer DNA dosimetry gold nanoparticles cancer therapy dose enhancement Monte Carlo simulation Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b3dd5d4af6ad419091e6ac96ac2b70d0
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spelling	oai:doaj.org-article:b3dd5d4af6ad419091e6ac96ac2b70d02021-11-25T16:39:24ZDNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement10.3390/app1122108562076-3417https://doaj.org/article/b3dd5d4af6ad419091e6ac96ac2b70d02021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10856https://doaj.org/toc/2076-3417Heavy atom nanoparticles, such as gold nanoparticles, are proven effective radiosensitizers in radiotherapy to enhance the dose delivery for cancer treatment. This study investigated the effectiveness of cancer cell killing, involving gold nanoparticle in proton radiation, by changing the nanoparticle size, proton beam energy, and distance between the nanoparticle and DNA. Monte Carlo (MC) simulation (Geant4-DNA code) was used to determine the dose enhancement in terms of dose enhancement ratio (DER), when a gold nanoparticle is present with the DNA. With varying nanoparticle size (radius = 15–50 nm), distance between the gold nanoparticle and DNA (30–130 nm), as well as proton beam energy (0.5–25 MeV) based on the simulation model, our results showed that the DER value increases with a decrease of distance between the gold nanoparticle and DNA and a decrease of proton beam energy. The maximum DER (1.83) is achieved with a 25 nm-radius gold nanoparticle, irradiated by a 0.5 MeV proton beam and 30 nm away from the DNA.Ngoc Han HuynhJames C. L. ChowMDPI AGarticleradiosensitizerDNA dosimetrygold nanoparticlescancer therapydose enhancementMonte Carlo simulationTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10856, p 10856 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiosensitizer DNA dosimetry gold nanoparticles cancer therapy dose enhancement Monte Carlo simulation Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	radiosensitizer DNA dosimetry gold nanoparticles cancer therapy dose enhancement Monte Carlo simulation Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Ngoc Han Huynh James C. L. Chow DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
description	Heavy atom nanoparticles, such as gold nanoparticles, are proven effective radiosensitizers in radiotherapy to enhance the dose delivery for cancer treatment. This study investigated the effectiveness of cancer cell killing, involving gold nanoparticle in proton radiation, by changing the nanoparticle size, proton beam energy, and distance between the nanoparticle and DNA. Monte Carlo (MC) simulation (Geant4-DNA code) was used to determine the dose enhancement in terms of dose enhancement ratio (DER), when a gold nanoparticle is present with the DNA. With varying nanoparticle size (radius = 15–50 nm), distance between the gold nanoparticle and DNA (30–130 nm), as well as proton beam energy (0.5–25 MeV) based on the simulation model, our results showed that the DER value increases with a decrease of distance between the gold nanoparticle and DNA and a decrease of proton beam energy. The maximum DER (1.83) is achieved with a 25 nm-radius gold nanoparticle, irradiated by a 0.5 MeV proton beam and 30 nm away from the DNA.
format	article
author	Ngoc Han Huynh James C. L. Chow
author_facet	Ngoc Han Huynh James C. L. Chow
author_sort	Ngoc Han Huynh
title	DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
title_short	DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
title_full	DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
title_fullStr	DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
title_full_unstemmed	DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement
title_sort	dna dosimetry with gold nanoparticle irradiated by proton beams: a monte carlo study on dose enhancement
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b3dd5d4af6ad419091e6ac96ac2b70d0
work_keys_str_mv	AT ngochanhuynh dnadosimetrywithgoldnanoparticleirradiatedbyprotonbeamsamontecarlostudyondoseenhancement AT jamesclchow dnadosimetrywithgoldnanoparticleirradiatedbyprotonbeamsamontecarlostudyondoseenhancement
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DNA Dosimetry with Gold Nanoparticle Irradiated by Proton Beams: A Monte Carlo Study on Dose Enhancement

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