Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol

Diazepam (DZP) is a benzodiazepine drug used as an anti-drug and sedative. It is often misused to induce or create euphoria in combination with other drugs (high or fly sensation) or administered alone. So far, screening for DZP abuse with sensitive analytical methods is needed, as its small concent...

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Autores principales:	Hasanah Aliya Nur, Susanti Ike, Marcellino Marcellino, Maranata Gabriella Josephine, Saputri Febrina Amelia, Pratiwi Rimadani
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	diazepam itaconic acid precipitation polymerisation molecularly imprinted solid-phase extraction solid-phase extraction propanol Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b3de6996633047d9855d8207732ed27a
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spelling	oai:doaj.org-article:b3de6996633047d9855d8207732ed27a2021-12-05T14:10:44ZMicrosphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol2391-542010.1515/chem-2021-0050https://doaj.org/article/b3de6996633047d9855d8207732ed27a2021-05-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0050https://doaj.org/toc/2391-5420Diazepam (DZP) is a benzodiazepine drug used as an anti-drug and sedative. It is often misused to induce or create euphoria in combination with other drugs (high or fly sensation) or administered alone. So far, screening for DZP abuse with sensitive analytical methods is needed, as its small concentrations make it difficult to detect. Increased sensitivity of the analytical method can be obtained by using a preparation method that selectively separates the analyte from the sample matrix. Molecularly imprinted polymer (MIP) is one of the preparation solutions with good selectivity, specificity, and sensitivity. MIP was made from DZP as a template, itaconic acid, and ethylene glycol dimethacrylate in a composition of 1:4:20. MIP was made by precipitation polymerisation to obtain microsphere polymer type. MIP had a binding capacity value of 0.0557 mg/g and followed the Freundlich isotherm. Application of the microsphere MIP on spiked blood serum resulted in a recovery of 105.63 ± 1.0% for MIP compared to 21.28 ± 0.4% for non-imprinted polymer, with the imprinting factor value reaching 4.96. Hence, MIP DZP with itaconic acid as a functional monomer and propanol as a porogen, fabricated by the precipitation polymerisation method, is a promising sorbent for DZP extraction in biological fluids.Hasanah Aliya NurSusanti IkeMarcellino MarcellinoMaranata Gabriella JosephineSaputri Febrina AmeliaPratiwi RimadaniDe Gruyterarticlediazepamitaconic acidprecipitation polymerisationmolecularly imprinted solid-phase extractionsolid-phase extractionpropanolChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 604-613 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diazepam itaconic acid precipitation polymerisation molecularly imprinted solid-phase extraction solid-phase extraction propanol Chemistry QD1-999
spellingShingle	diazepam itaconic acid precipitation polymerisation molecularly imprinted solid-phase extraction solid-phase extraction propanol Chemistry QD1-999 Hasanah Aliya Nur Susanti Ike Marcellino Marcellino Maranata Gabriella Josephine Saputri Febrina Amelia Pratiwi Rimadani Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol
description	Diazepam (DZP) is a benzodiazepine drug used as an anti-drug and sedative. It is often misused to induce or create euphoria in combination with other drugs (high or fly sensation) or administered alone. So far, screening for DZP abuse with sensitive analytical methods is needed, as its small concentrations make it difficult to detect. Increased sensitivity of the analytical method can be obtained by using a preparation method that selectively separates the analyte from the sample matrix. Molecularly imprinted polymer (MIP) is one of the preparation solutions with good selectivity, specificity, and sensitivity. MIP was made from DZP as a template, itaconic acid, and ethylene glycol dimethacrylate in a composition of 1:4:20. MIP was made by precipitation polymerisation to obtain microsphere polymer type. MIP had a binding capacity value of 0.0557 mg/g and followed the Freundlich isotherm. Application of the microsphere MIP on spiked blood serum resulted in a recovery of 105.63 ± 1.0% for MIP compared to 21.28 ± 0.4% for non-imprinted polymer, with the imprinting factor value reaching 4.96. Hence, MIP DZP with itaconic acid as a functional monomer and propanol as a porogen, fabricated by the precipitation polymerisation method, is a promising sorbent for DZP extraction in biological fluids.
format	article
author	Hasanah Aliya Nur Susanti Ike Marcellino Marcellino Maranata Gabriella Josephine Saputri Febrina Amelia Pratiwi Rimadani
author_facet	Hasanah Aliya Nur Susanti Ike Marcellino Marcellino Maranata Gabriella Josephine Saputri Febrina Amelia Pratiwi Rimadani
author_sort	Hasanah Aliya Nur
title	Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol
title_short	Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol
title_full	Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol
title_fullStr	Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol
title_full_unstemmed	Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol
title_sort	microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/b3de6996633047d9855d8207732ed27a
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Microsphere molecularly imprinted solid-phase extraction for diazepam analysis using itaconic acid as a monomer in propanol

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