Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Yifang Li, Yanzhen Chen, Xing Tian, Shanshan Zhang, Jian Jiao Department of Gastroenterolgy & Hepatology, China-Japan Union Hospital, Jilin University, Changchun, 130033, People’s Republic of ChinaCorrespondence: Jian JiaoDepartment of Gastroenterology & Hepatology, China-J...

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Autores principales:	Li Y, Chen Y, Tian X, Zhang S, Jiao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obese non-obese non-alcoholic liver disease gender characteristic Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b3de97bbf0444e6ebed9076b1189abb6
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spelling	oai:doaj.org-article:b3de97bbf0444e6ebed9076b1189abb62021-12-02T14:28:52ZComparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)1178-7007https://doaj.org/article/b3de97bbf0444e6ebed9076b1189abb62021-05-01T00:00:00Zhttps://www.dovepress.com/comparison-of-clinical-characteristics-between-obese-and-non-obese-pat-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Yifang Li, Yanzhen Chen, Xing Tian, Shanshan Zhang, Jian Jiao Department of Gastroenterolgy & Hepatology, China-Japan Union Hospital, Jilin University, Changchun, 130033, People’s Republic of ChinaCorrespondence: Jian JiaoDepartment of Gastroenterology & Hepatology, China-Japan Union Hospital, Jilin University, Changchun, People’s Republic of ChinaTel +86 13756009567Fax +86 0431-84995850Email jjian@jlu.edu.cnObjective: Non-alcoholic fatty liver disease (NAFLD), previously thought to predominantly affect obese individuals, has also been shown to occur in subjects who have a relatively normal body mass index (BMI). Due to the normal BMI, non-obese NAFLD are easily to be ignored and eventually lead to potential liver injuries.Methods: A population-based cross-sectional study was conducted on 1608 cases with normal serum alanine aminotransferase (ALT) levels who were divided into an obese group (BMI ≥ 25 kg/m2) and a non-obese group (BMI < 25 kg/m2). NAFLD was diagnosed by ultrasound and Fibro Scan examination. Non-obese populations were divided into NAFLD group (CAP ≥ 240 db/m) and non-NAFLD group (CAP < 240 db/m). The incidence of NAFLD in the obese and non-obese populations and constituent ratios of genders, age, and serum levels of triglycerides (TG), cholesterol (CHOL), and blood glucose were compared. Risk factors of NAFLD in non-obese people were analyzed by multivariate logistics regression.Results: The occurrence of NAFLD was higher in the obese group than in the non-obese group, regardless of gender (P < 0.001). In the non-obese group, the occurrence of NAFLD in female patients was lower than that in male (P=0.001). The occurrence of NAFLD increased with age, with 50– 59 years being the peak age of incidence in both male and female. The peak age of NAFLD occurrence in non-obese male patients was more delayed than that in obese male patients. BMI (OR=1.311, P=0.000) and TG (OR=2.545, P=0.000) were risk factors for NAFLD in the non-obese population.Conclusion: Compared with obese population, the incidence of NAFLD in non-obese population was relatively low and more frequently in male than in female, the peak age of NAFLD occurrence in non-obese male patients was also delayed. BMI and TG should still be controlled to avoid the occurrence of NAFLD although the BMI of such patients is normal.Keywords: obese, non-obese, non-alcoholic liver disease, gender, characteristicLi YChen YTian XZhang SJiao JDove Medical Pressarticleobesenon-obesenon-alcoholic liver diseasegendercharacteristicSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2029-2039 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obese non-obese non-alcoholic liver disease gender characteristic Specialties of internal medicine RC581-951
spellingShingle	obese non-obese non-alcoholic liver disease gender characteristic Specialties of internal medicine RC581-951 Li Y Chen Y Tian X Zhang S Jiao J Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
description	Yifang Li, Yanzhen Chen, Xing Tian, Shanshan Zhang, Jian Jiao Department of Gastroenterolgy & Hepatology, China-Japan Union Hospital, Jilin University, Changchun, 130033, People’s Republic of ChinaCorrespondence: Jian JiaoDepartment of Gastroenterology & Hepatology, China-Japan Union Hospital, Jilin University, Changchun, People’s Republic of ChinaTel +86 13756009567Fax +86 0431-84995850Email jjian@jlu.edu.cnObjective: Non-alcoholic fatty liver disease (NAFLD), previously thought to predominantly affect obese individuals, has also been shown to occur in subjects who have a relatively normal body mass index (BMI). Due to the normal BMI, non-obese NAFLD are easily to be ignored and eventually lead to potential liver injuries.Methods: A population-based cross-sectional study was conducted on 1608 cases with normal serum alanine aminotransferase (ALT) levels who were divided into an obese group (BMI ≥ 25 kg/m2) and a non-obese group (BMI < 25 kg/m2). NAFLD was diagnosed by ultrasound and Fibro Scan examination. Non-obese populations were divided into NAFLD group (CAP ≥ 240 db/m) and non-NAFLD group (CAP < 240 db/m). The incidence of NAFLD in the obese and non-obese populations and constituent ratios of genders, age, and serum levels of triglycerides (TG), cholesterol (CHOL), and blood glucose were compared. Risk factors of NAFLD in non-obese people were analyzed by multivariate logistics regression.Results: The occurrence of NAFLD was higher in the obese group than in the non-obese group, regardless of gender (P < 0.001). In the non-obese group, the occurrence of NAFLD in female patients was lower than that in male (P=0.001). The occurrence of NAFLD increased with age, with 50– 59 years being the peak age of incidence in both male and female. The peak age of NAFLD occurrence in non-obese male patients was more delayed than that in obese male patients. BMI (OR=1.311, P=0.000) and TG (OR=2.545, P=0.000) were risk factors for NAFLD in the non-obese population.Conclusion: Compared with obese population, the incidence of NAFLD in non-obese population was relatively low and more frequently in male than in female, the peak age of NAFLD occurrence in non-obese male patients was also delayed. BMI and TG should still be controlled to avoid the occurrence of NAFLD although the BMI of such patients is normal.Keywords: obese, non-obese, non-alcoholic liver disease, gender, characteristic
format	article
author	Li Y Chen Y Tian X Zhang S Jiao J
author_facet	Li Y Chen Y Tian X Zhang S Jiao J
author_sort	Li Y
title	Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
title_short	Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
title_full	Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
title_fullStr	Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
title_full_unstemmed	Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
title_sort	comparison of clinical characteristics between obese and non-obese patients with nonalcoholic fatty liver disease (nafld)
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b3de97bbf0444e6ebed9076b1189abb6
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Comparison of Clinical Characteristics Between Obese and Non-Obese Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

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