A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis.

Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, plays a crucial role in driving immunopathology at the...

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Main Authors:	Junyan Liu, Hubertine M E Willems, Emily A Sansevere, Stefanie Allert, Katherine S Barker, David J Lowes, Andrew C Dixson, Zhenbo Xu, Jian Miao, Christian DeJarnette, Helene Tournu, Glen E Palmer, Jonathan P Richardson, Francisco N Barrera, Bernhard Hube, Julian R Naglik, Brian M Peters
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2021
Subjects:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/b3e2ce06c5484147bdbc2ffbdee60a64
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https://doaj.org/article/b3e2ce06c5484147bdbc2ffbdee60a64

A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis.

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