Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder

Martina Zvéřová,1 Jana Hroudová,1,2 Zdeněk Fi&scaron;ar,1 Hana Hansíková,3 Lucie Kali&scaron;ová,1 Eva Kitzlerová,1 Alena Lambertová,1 Jiří Raboch1 1Department of Psychiatry, First Faculty of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Bipolar affective disorder Unipolar depression Blood platelet Mitochondrion Electron transport chain complexes Respiratory rate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b3e3caaac18746ac84142585b0deb743
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b3e3caaac18746ac84142585b0deb743
record_format	dspace
spelling	oai:doaj.org-article:b3e3caaac18746ac84142585b0deb7432021-12-02T00:24:26ZDisturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder1178-2021https://doaj.org/article/b3e3caaac18746ac84142585b0deb7432019-01-01T00:00:00Zhttps://www.dovepress.com/disturbances-of-mitochondrial-parameters-to-distinguish-patients-with--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Martina Zvéřová,1 Jana Hroudová,1,2 Zdeněk Fi&scaron;ar,1 Hana Hansíková,3 Lucie Kali&scaron;ová,1 Eva Kitzlerová,1 Alena Lambertová,1 Jiří Raboch1 1Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic; 2Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague 2, Czech Republic; 3Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic Background: Mitochondrial dysfunctions are implicated in the pathophysiology of mood disorders. We measured and examined the following selected mitochondrial parameters: citrate synthase (CS) activity, electron transport system (ETS) complex (complexes I, II, and IV) activities, and mitochondrial respiration in blood platelets. Patients and methods: The analyses were performed for 24 patients suffering from a depressive episode of bipolar affective disorder (BD), compared to 68 patients with MDD and 104 healthy controls. BD and unipolar depression were clinically evaluated using well-established diagnostic scales and questionnaires. Results: The CS, complex II, and complex IV activities were decreased in the depressive episode of BD patients; complex I and complex I/CS ratio were significantly increased compared to healthy controls. We observed significantly decreased complex II and CS activities in patients suffering from MDD compared to controls. Decreased respiration after complex I inhibition and increased residual respiration were found in depressive BD patients compared to controls. Physiological respiration and capacity of the ETS were decreased, and respiration after complex I inhibition was increased in MDD patients, compared to controls. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities. Conclusion: We can conclude that complex I and its abnormal activity contribute to the defects in cellular energy metabolism during a depressive episode of BD. The observed parameters could be used in a panel of biomarkers that could selectively distinguish BD depression from MDD and can be easily examined from blood elements. Keywords: affective disorder, biomarker, oxidative phosphorylation, mitochondrial enzyme, plateletZvěřová MHroudová JFišar ZHansíková HKališová LKitzlerová ELambertová ARaboch JDove Medical PressarticleBipolar affective disorder Unipolar depression Blood platelet Mitochondrion Electron transport chain complexes Respiratory rateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 233-240 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bipolar affective disorder Unipolar depression Blood platelet Mitochondrion Electron transport chain complexes Respiratory rate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Bipolar affective disorder Unipolar depression Blood platelet Mitochondrion Electron transport chain complexes Respiratory rate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zvěřová M Hroudová J Fišar Z Hansíková H Kališová L Kitzlerová E Lambertová A Raboch J Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder
description	Martina Zvéřová,1 Jana Hroudová,1,2 Zdeněk Fi&scaron;ar,1 Hana Hansíková,3 Lucie Kali&scaron;ová,1 Eva Kitzlerová,1 Alena Lambertová,1 Jiří Raboch1 1Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic; 2Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague 2, Czech Republic; 3Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic Background: Mitochondrial dysfunctions are implicated in the pathophysiology of mood disorders. We measured and examined the following selected mitochondrial parameters: citrate synthase (CS) activity, electron transport system (ETS) complex (complexes I, II, and IV) activities, and mitochondrial respiration in blood platelets. Patients and methods: The analyses were performed for 24 patients suffering from a depressive episode of bipolar affective disorder (BD), compared to 68 patients with MDD and 104 healthy controls. BD and unipolar depression were clinically evaluated using well-established diagnostic scales and questionnaires. Results: The CS, complex II, and complex IV activities were decreased in the depressive episode of BD patients; complex I and complex I/CS ratio were significantly increased compared to healthy controls. We observed significantly decreased complex II and CS activities in patients suffering from MDD compared to controls. Decreased respiration after complex I inhibition and increased residual respiration were found in depressive BD patients compared to controls. Physiological respiration and capacity of the ETS were decreased, and respiration after complex I inhibition was increased in MDD patients, compared to controls. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities. Conclusion: We can conclude that complex I and its abnormal activity contribute to the defects in cellular energy metabolism during a depressive episode of BD. The observed parameters could be used in a panel of biomarkers that could selectively distinguish BD depression from MDD and can be easily examined from blood elements. Keywords: affective disorder, biomarker, oxidative phosphorylation, mitochondrial enzyme, platelet
format	article
author	Zvěřová M Hroudová J Fišar Z Hansíková H Kališová L Kitzlerová E Lambertová A Raboch J
author_facet	Zvěřová M Hroudová J Fišar Z Hansíková H Kališová L Kitzlerová E Lambertová A Raboch J
author_sort	Zvěřová M
title	Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder
title_short	Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder
title_full	Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder
title_fullStr	Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder
title_full_unstemmed	Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder
title_sort	disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b3e3caaac18746ac84142585b0deb743
work_keys_str_mv	AT zverovam disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder AT hroudovaj disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder AT fisarz disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder AT hansikovah disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder AT kalisoval disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder AT kitzlerovae disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder AT lambertovaa disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder AT rabochj disturbancesofmitochondrialparameterstodistinguishpatientswithdepressiveepisodeofbipolardisorderandmajordepressivedisorder
_version_	1718403760854663168

Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder

Ejemplares similares