SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system

Abstract The three SoxD proteins, Sox5, Sox6 and Sox13, represent closely related transcription factors with important roles during development. In the developing nervous system, SoxD proteins have so far been primarily studied in oligodendroglial cells and in interneurons of brain and spinal cord....

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Autores principales:	Ella Ittner, Anna C. Hartwig, Olga Elsesser, Hannah M. Wüst, Franziska Fröb, Miriam Wedel, Margit Schimmel, Ernst R. Tamm, Michael Wegner, Elisabeth Sock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3e535b773874646bf0b6c01712929f9
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spelling	oai:doaj.org-article:b3e535b773874646bf0b6c01712929f92021-12-02T16:15:06ZSoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system10.1038/s41598-021-93437-92045-2322https://doaj.org/article/b3e535b773874646bf0b6c01712929f92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93437-9https://doaj.org/toc/2045-2322Abstract The three SoxD proteins, Sox5, Sox6 and Sox13, represent closely related transcription factors with important roles during development. In the developing nervous system, SoxD proteins have so far been primarily studied in oligodendroglial cells and in interneurons of brain and spinal cord. In oligodendroglial cells, Sox5 and Sox6 jointly maintain the precursor state, interfere with terminal differentiation, and thereby ensure the proper timing of myelination in the central nervous system. Here we studied the role of SoxD proteins in Schwann cells, the functional counterpart of oligodendrocytes in the peripheral nervous system. We show that Schwann cells express Sox5 and Sox13 but not Sox6. Expression was transient and ceased with the onset of terminal differentiation. In mice with early Schwann cell-specific deletion of both Sox5 and Sox13, embryonic Schwann cell development was not substantially affected and progressed normally into the promyelinating stage. However, there was a mild and transient delay in the myelination of the peripheral nervous system of these mice. We therefore conclude that SoxD proteins—in stark contrast to their action in oligodendrocytes—promote differentiation and myelination in Schwann cells.Ella IttnerAnna C. HartwigOlga ElsesserHannah M. WüstFranziska FröbMiriam WedelMargit SchimmelErnst R. TammMichael WegnerElisabeth SockNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ella Ittner Anna C. Hartwig Olga Elsesser Hannah M. Wüst Franziska Fröb Miriam Wedel Margit Schimmel Ernst R. Tamm Michael Wegner Elisabeth Sock SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system
description	Abstract The three SoxD proteins, Sox5, Sox6 and Sox13, represent closely related transcription factors with important roles during development. In the developing nervous system, SoxD proteins have so far been primarily studied in oligodendroglial cells and in interneurons of brain and spinal cord. In oligodendroglial cells, Sox5 and Sox6 jointly maintain the precursor state, interfere with terminal differentiation, and thereby ensure the proper timing of myelination in the central nervous system. Here we studied the role of SoxD proteins in Schwann cells, the functional counterpart of oligodendrocytes in the peripheral nervous system. We show that Schwann cells express Sox5 and Sox13 but not Sox6. Expression was transient and ceased with the onset of terminal differentiation. In mice with early Schwann cell-specific deletion of both Sox5 and Sox13, embryonic Schwann cell development was not substantially affected and progressed normally into the promyelinating stage. However, there was a mild and transient delay in the myelination of the peripheral nervous system of these mice. We therefore conclude that SoxD proteins—in stark contrast to their action in oligodendrocytes—promote differentiation and myelination in Schwann cells.
format	article
author	Ella Ittner Anna C. Hartwig Olga Elsesser Hannah M. Wüst Franziska Fröb Miriam Wedel Margit Schimmel Ernst R. Tamm Michael Wegner Elisabeth Sock
author_facet	Ella Ittner Anna C. Hartwig Olga Elsesser Hannah M. Wüst Franziska Fröb Miriam Wedel Margit Schimmel Ernst R. Tamm Michael Wegner Elisabeth Sock
author_sort	Ella Ittner
title	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system
title_short	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system
title_full	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system
title_fullStr	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system
title_full_unstemmed	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system
title_sort	soxd transcription factor deficiency in schwann cells delays myelination in the developing peripheral nervous system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3e535b773874646bf0b6c01712929f9
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SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system

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