Sex differences in genetic architecture of complex phenotypes?
We examined sex differences in familial resemblance for a broad range of behavioral, psychiatric and health related phenotypes (122 complex traits) in children and adults. There is a renewed interest in the importance of genotype by sex interaction in, for example, genome-wide association (GWA) stud...
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Public Library of Science (PLoS)
2012
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oai:doaj.org-article:b3e6ab0a60f4479ab989a9b7c09ee13e2021-11-18T08:04:44ZSex differences in genetic architecture of complex phenotypes?1932-620310.1371/journal.pone.0047371https://doaj.org/article/b3e6ab0a60f4479ab989a9b7c09ee13e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272036/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203We examined sex differences in familial resemblance for a broad range of behavioral, psychiatric and health related phenotypes (122 complex traits) in children and adults. There is a renewed interest in the importance of genotype by sex interaction in, for example, genome-wide association (GWA) studies of complex phenotypes. If different genes play a role across sex, GWA studies should consider the effect of genetic variants separately in men and women, which affects statistical power. Twin and family studies offer an opportunity to compare resemblance between opposite-sex family members to the resemblance between same-sex relatives, thereby presenting a test of quantitative and qualitative sex differences in the genetic architecture of complex traits. We analyzed data on lifestyle, personality, psychiatric disorder, health, growth, development and metabolic traits in dizygotic (DZ) same-sex and opposite-sex twins, as these siblings are perfectly matched for age and prenatal exposures. Sample size varied from slightly over 300 subjects for measures of brain function such as EEG power to over 30,000 subjects for childhood psychopathology and birth weight. For most phenotypes, sample sizes were large, with an average sample size of 9027 individuals. By testing whether the resemblance in DZ opposite-sex pairs is the same as in DZ same-sex pairs, we obtain evidence for genetic qualitative sex-differences in the genetic architecture of complex traits for 4% of phenotypes. We conclude that for most traits that were examined, the current evidence is that same the genes are operating in men and women.Jacqueline M VinkMeike BartelsToos C E M van BeijsterveldtJenny van DongenJenny H D A van BeekMarijn A DistelMarleen H M de MoorDirk J A SmitCamelia C MinicaLannie LigthartLot M GeelsAbdel AbdellaouiChristel M MiddeldorpJouke Jan HottengaGonneke WillemsenEco J C de GeusDorret I BoomsmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e47371 (2012) |
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| collection |
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| language |
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| topic |
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| spellingShingle |
Medicine R Science Q Jacqueline M Vink Meike Bartels Toos C E M van Beijsterveldt Jenny van Dongen Jenny H D A van Beek Marijn A Distel Marleen H M de Moor Dirk J A Smit Camelia C Minica Lannie Ligthart Lot M Geels Abdel Abdellaoui Christel M Middeldorp Jouke Jan Hottenga Gonneke Willemsen Eco J C de Geus Dorret I Boomsma Sex differences in genetic architecture of complex phenotypes? |
| description |
We examined sex differences in familial resemblance for a broad range of behavioral, psychiatric and health related phenotypes (122 complex traits) in children and adults. There is a renewed interest in the importance of genotype by sex interaction in, for example, genome-wide association (GWA) studies of complex phenotypes. If different genes play a role across sex, GWA studies should consider the effect of genetic variants separately in men and women, which affects statistical power. Twin and family studies offer an opportunity to compare resemblance between opposite-sex family members to the resemblance between same-sex relatives, thereby presenting a test of quantitative and qualitative sex differences in the genetic architecture of complex traits. We analyzed data on lifestyle, personality, psychiatric disorder, health, growth, development and metabolic traits in dizygotic (DZ) same-sex and opposite-sex twins, as these siblings are perfectly matched for age and prenatal exposures. Sample size varied from slightly over 300 subjects for measures of brain function such as EEG power to over 30,000 subjects for childhood psychopathology and birth weight. For most phenotypes, sample sizes were large, with an average sample size of 9027 individuals. By testing whether the resemblance in DZ opposite-sex pairs is the same as in DZ same-sex pairs, we obtain evidence for genetic qualitative sex-differences in the genetic architecture of complex traits for 4% of phenotypes. We conclude that for most traits that were examined, the current evidence is that same the genes are operating in men and women. |
| format |
article |
| author |
Jacqueline M Vink Meike Bartels Toos C E M van Beijsterveldt Jenny van Dongen Jenny H D A van Beek Marijn A Distel Marleen H M de Moor Dirk J A Smit Camelia C Minica Lannie Ligthart Lot M Geels Abdel Abdellaoui Christel M Middeldorp Jouke Jan Hottenga Gonneke Willemsen Eco J C de Geus Dorret I Boomsma |
| author_facet |
Jacqueline M Vink Meike Bartels Toos C E M van Beijsterveldt Jenny van Dongen Jenny H D A van Beek Marijn A Distel Marleen H M de Moor Dirk J A Smit Camelia C Minica Lannie Ligthart Lot M Geels Abdel Abdellaoui Christel M Middeldorp Jouke Jan Hottenga Gonneke Willemsen Eco J C de Geus Dorret I Boomsma |
| author_sort |
Jacqueline M Vink |
| title |
Sex differences in genetic architecture of complex phenotypes? |
| title_short |
Sex differences in genetic architecture of complex phenotypes? |
| title_full |
Sex differences in genetic architecture of complex phenotypes? |
| title_fullStr |
Sex differences in genetic architecture of complex phenotypes? |
| title_full_unstemmed |
Sex differences in genetic architecture of complex phenotypes? |
| title_sort |
sex differences in genetic architecture of complex phenotypes? |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/b3e6ab0a60f4479ab989a9b7c09ee13e |
| work_keys_str_mv |
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| _version_ |
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