Estimating influenza deaths in Canada, 1992-2009.

<h4>Background</h4>Poisson regression modelling has been widely used to estimate the disease burden attributable to influenza, though not without concerns that some of the excess burden could be due to other causes. This study aims to provide annual estimates of the mortality and hospita...

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Autores principales:	Dena L Schanzer, Claire Sevenhuysen, Brian Winchester, Teresa Mersereau
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3e7bbddd5774cf2938e935ccd167e67
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spelling	oai:doaj.org-article:b3e7bbddd5774cf2938e935ccd167e672021-11-18T08:44:27ZEstimating influenza deaths in Canada, 1992-2009.1932-620310.1371/journal.pone.0080481https://doaj.org/article/b3e7bbddd5774cf2938e935ccd167e672013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312225/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Poisson regression modelling has been widely used to estimate the disease burden attributable to influenza, though not without concerns that some of the excess burden could be due to other causes. This study aims to provide annual estimates of the mortality and hospitalization burden attributable to both seasonal influenza and the 2009 A/H1N1 pandemic influenza for Canada, and to discuss issues related to the reliability of these estimates.<h4>Methods</h4>Weekly time-series for all-cause mortality and regression models were used to estimate the number of deaths in Canada attributable to influenza from September 1992 to December 2009. To assess their robustness, the annual estimates derived from different parameterizations of the regression model for all-cause mortality were compared. In addition, the association between the annual estimates for mortality and hospitalization by age group, underlying cause of death or primary reason for admission and discharge status is discussed.<h4>Results</h4>The crude influenza-attributed mortality rate based on all-cause mortality and averaged over 17 influenza seasons prior to the 2009 A/H1N1 pandemic was 11.3 (95%CI, 10.5 - 12.1) deaths per 100 000 population per year, or an average of 3,500 (95%CI, 3,200 - 3,700) deaths per year attributable to seasonal influenza. The estimated annual rates ranged from undetectable at the ecological level to more than 6000 deaths per year over the three A/Sydney seasons. In comparison, we attributed an estimated 740 deaths (95%CI, 350-1500) to A(H1N1)pdm09. Annual estimates from different model parameterizations were strongly correlated, as were estimates for mortality and morbidity; the higher A(H1N1)pdm09 burden in younger age groups was the most notable exception.<h4>Interpretation</h4>With the exception of some of the Serfling models, differences in the ecological estimates of the disease burden attributable to influenza were small in comparison to the variation in disease burden from one season to another.Dena L SchanzerClaire SevenhuysenBrian WinchesterTeresa MersereauPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80481 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dena L Schanzer Claire Sevenhuysen Brian Winchester Teresa Mersereau Estimating influenza deaths in Canada, 1992-2009.
description	<h4>Background</h4>Poisson regression modelling has been widely used to estimate the disease burden attributable to influenza, though not without concerns that some of the excess burden could be due to other causes. This study aims to provide annual estimates of the mortality and hospitalization burden attributable to both seasonal influenza and the 2009 A/H1N1 pandemic influenza for Canada, and to discuss issues related to the reliability of these estimates.<h4>Methods</h4>Weekly time-series for all-cause mortality and regression models were used to estimate the number of deaths in Canada attributable to influenza from September 1992 to December 2009. To assess their robustness, the annual estimates derived from different parameterizations of the regression model for all-cause mortality were compared. In addition, the association between the annual estimates for mortality and hospitalization by age group, underlying cause of death or primary reason for admission and discharge status is discussed.<h4>Results</h4>The crude influenza-attributed mortality rate based on all-cause mortality and averaged over 17 influenza seasons prior to the 2009 A/H1N1 pandemic was 11.3 (95%CI, 10.5 - 12.1) deaths per 100 000 population per year, or an average of 3,500 (95%CI, 3,200 - 3,700) deaths per year attributable to seasonal influenza. The estimated annual rates ranged from undetectable at the ecological level to more than 6000 deaths per year over the three A/Sydney seasons. In comparison, we attributed an estimated 740 deaths (95%CI, 350-1500) to A(H1N1)pdm09. Annual estimates from different model parameterizations were strongly correlated, as were estimates for mortality and morbidity; the higher A(H1N1)pdm09 burden in younger age groups was the most notable exception.<h4>Interpretation</h4>With the exception of some of the Serfling models, differences in the ecological estimates of the disease burden attributable to influenza were small in comparison to the variation in disease burden from one season to another.
format	article
author	Dena L Schanzer Claire Sevenhuysen Brian Winchester Teresa Mersereau
author_facet	Dena L Schanzer Claire Sevenhuysen Brian Winchester Teresa Mersereau
author_sort	Dena L Schanzer
title	Estimating influenza deaths in Canada, 1992-2009.
title_short	Estimating influenza deaths in Canada, 1992-2009.
title_full	Estimating influenza deaths in Canada, 1992-2009.
title_fullStr	Estimating influenza deaths in Canada, 1992-2009.
title_full_unstemmed	Estimating influenza deaths in Canada, 1992-2009.
title_sort	estimating influenza deaths in canada, 1992-2009.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b3e7bbddd5774cf2938e935ccd167e67
work_keys_str_mv	AT denalschanzer estimatinginfluenzadeathsincanada19922009 AT clairesevenhuysen estimatinginfluenzadeathsincanada19922009 AT brianwinchester estimatinginfluenzadeathsincanada19922009 AT teresamersereau estimatinginfluenzadeathsincanada19922009
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Estimating influenza deaths in Canada, 1992-2009.

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