Evaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction
Background: High-intensity statin (HIS) therapy is widely recommended for secondary prevention after an acute myocardial infarction (AMI). The 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidemia guidelines have lowered the target low-density lipoprotein chol...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Permanyer
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b3e7bdb6828d4c54a4eebc3398010950 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b3e7bdb6828d4c54a4eebc3398010950 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b3e7bdb6828d4c54a4eebc33980109502021-11-09T14:24:29ZEvaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction10.24875/RIC.210001520034-83762564-8896https://doaj.org/article/b3e7bdb6828d4c54a4eebc33980109502021-01-01T00:00:00Zhttps://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=380https://doaj.org/toc/0034-8376https://doaj.org/toc/2564-8896Background: High-intensity statin (HIS) therapy is widely recommended for secondary prevention after an acute myocardial infarction (AMI). The 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidemia guidelines have lowered the target low-density lipoprotein cholesterol (LDL-C) level, which necessitates a more frequent use of nonstatin therapies. Objectives: The objectives of the study were to investigate the rate of LDL-C target attainment for secondary prevention in AMI patients. Methods: This retrospective investigation included 1360 patients diagnosed with AMI in a tertiary heart center. Lipid parameters were collected within 24 h of admission and within 1 year after discharge. The medications used were retrieved from medical records, and the lowest LDL-C levels after statin treatment were used to assess the effectiveness of the therapy. LDL-C target attainment was defined according to the 2016 ESC/EAS dyslipidemia guidelines as an LDL-C level of < 70 mg/dL and a ≥ 50% reduction from baseline. In addition, the rate of LDL-C target attainment according to the 2019 ESC/EAS guidelines was defined as an LDL-C level of < 55 mg/dL and a ≥ 50% reduction from baseline. Results: In total, 502 (36.9%) and 247 (18.2%) patients reached the LDL-C targets according to the 2016 and 2019 ESC/EAS guidelines, respectively. The admission LDL-C levels were significantly lower and HIS treatment was used more frequently in patients who subsequently attained the LDL-C goal. Remarkably, 461 (34%) patients failed to reach the LDL-C goals despite HIS treatment. Only 27 (1.9%) patients were prescribed ezetimibe. Conclusion: The rate of LDL-C goal attainment in AMI patients was low, which indicates the need for combination statin and non-statin lipid-lowering therapies. Barış ŞimşekDuygu İnanTufan ÇınarAhmet Cagdas-YumurtaşVeysel Ozan-TanıkGonul Zerenİlhan İlker-AvcıCan Yücel-KarabayBarış GüngörLale TokgozoğluPermanyerarticleStatin. Low-density lipoprotein. European Society of Cardiology. Acute myocardial infarction.Internal medicineRC31-1245ENRevista de Investigación Clínica, Vol 73, Iss 6 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Statin. Low-density lipoprotein. European Society of Cardiology. Acute myocardial infarction. Internal medicine RC31-1245 |
| spellingShingle |
Statin. Low-density lipoprotein. European Society of Cardiology. Acute myocardial infarction. Internal medicine RC31-1245 Barış Şimşek Duygu İnan Tufan Çınar Ahmet Cagdas-Yumurtaş Veysel Ozan-Tanık Gonul Zeren İlhan İlker-Avcı Can Yücel-Karabay Barış Güngör Lale Tokgozoğlu Evaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction |
| description |
Background: High-intensity statin (HIS) therapy is widely recommended for secondary prevention after an acute myocardial infarction (AMI). The 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidemia guidelines have lowered the target low-density lipoprotein cholesterol (LDL-C) level, which necessitates a more frequent use of nonstatin therapies. Objectives: The objectives of the study were to investigate the rate of LDL-C target attainment for secondary prevention in AMI patients. Methods: This retrospective investigation included 1360 patients diagnosed with AMI in a tertiary heart center. Lipid parameters were collected within 24 h of admission and within 1 year after discharge. The medications used were retrieved from medical records, and the lowest LDL-C levels after statin treatment were used to assess the effectiveness of the therapy. LDL-C target attainment was defined according to the 2016 ESC/EAS dyslipidemia guidelines as an LDL-C level of < 70 mg/dL and a ≥ 50% reduction from baseline. In addition, the rate of LDL-C target attainment according to the 2019 ESC/EAS guidelines was defined as an LDL-C level of < 55 mg/dL and a ≥ 50% reduction from baseline. Results: In total, 502 (36.9%) and 247 (18.2%) patients reached the LDL-C targets according to the 2016 and 2019 ESC/EAS guidelines, respectively. The admission LDL-C levels were significantly lower and HIS treatment was used more frequently in patients who subsequently attained the LDL-C goal. Remarkably, 461 (34%) patients failed to reach the LDL-C goals despite HIS treatment. Only 27 (1.9%) patients were prescribed ezetimibe. Conclusion: The rate of LDL-C goal attainment in AMI patients was low, which indicates the need for combination statin and non-statin lipid-lowering therapies.
|
| format |
article |
| author |
Barış Şimşek Duygu İnan Tufan Çınar Ahmet Cagdas-Yumurtaş Veysel Ozan-Tanık Gonul Zeren İlhan İlker-Avcı Can Yücel-Karabay Barış Güngör Lale Tokgozoğlu |
| author_facet |
Barış Şimşek Duygu İnan Tufan Çınar Ahmet Cagdas-Yumurtaş Veysel Ozan-Tanık Gonul Zeren İlhan İlker-Avcı Can Yücel-Karabay Barış Güngör Lale Tokgozoğlu |
| author_sort |
Barış Şimşek |
| title |
Evaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction |
| title_short |
Evaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction |
| title_full |
Evaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction |
| title_fullStr |
Evaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction |
| title_full_unstemmed |
Evaluation of Low-density Lipoprotein Cholesterol Target Attainment Rates According to the 2016 and 2019 European Society of Cardiology/ European Atherosclerosis Society Dyslipidemia Guidelines for Secondary Prevention in Patients with Acute Myocardial Infarction |
| title_sort |
evaluation of low-density lipoprotein cholesterol target attainment rates according to the 2016 and 2019 european society of cardiology/ european atherosclerosis society dyslipidemia guidelines for secondary prevention in patients with acute myocardial infarction |
| publisher |
Permanyer |
| publishDate |
2021 |
| url |
https://doaj.org/article/b3e7bdb6828d4c54a4eebc3398010950 |
| work_keys_str_mv |
AT bar305351350im351ek evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT duygu304nan evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT tufan199305nar evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT ahmetcagdasyumurta351 evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT veyselozantanık evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT gonulzeren evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT 304lhan304lkeravc305 evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT canyu776celkarabay evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT bar305351gu776ng246r evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction AT laletokgozo287lu evaluationoflowdensitylipoproteincholesteroltargetattainmentratesaccordingtothe2016and2019europeansocietyofcardiologyeuropeanatherosclerosissocietydyslipidemiaguidelinesforsecondarypreventioninpatientswithacutemyocardialinfarction |
| _version_ |
1718440956822290432 |