(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY

An antimicrobial and antifungal activity of new derivatives of (imidazole-5-yl)ylidenthiazolidinones and its dependence on the substance structure and the type of substitutes in the imidazole and thiazole nucleus have been investigated. It was found that the sulphur of thiazolidone section is the ke...

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Autores principales:	Vitaliy CHORNOUS, Alina GROZAV, Victoria ANTONIYCHUK, Nina YAKOVYCHUK, Mykhaylo VOVK
Formato:	article
Lenguaje:	EN
Publicado:	Stefan cel Mare University of Suceava 2019
Materias:	organic synthesis imidazoles thiazolidinones antimicrobial and antifungal activity foodstuff treat-ment and production Food processing and manufacture TP368-456
Acceso en línea:	https://doaj.org/article/b3e7fa911695453caa0703bc4eb23251
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spelling	oai:doaj.org-article:b3e7fa911695453caa0703bc4eb232512021-12-02T19:35:52Z(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY2068-66092559-6381https://doaj.org/article/b3e7fa911695453caa0703bc4eb232512019-03-01T00:00:00Zhttp://www.fia.usv.ro/fiajournal/index.php/FENS/article/view/624/583https://doaj.org/toc/2068-6609https://doaj.org/toc/2559-6381An antimicrobial and antifungal activity of new derivatives of (imidazole-5-yl)ylidenthiazolidinones and its dependence on the substance structure and the type of substitutes in the imidazole and thiazole nucleus have been investigated. It was found that the sulphur of thiazolidone section is the key factor that governs antimicrobial activity of the compounds. High antibacterial and antifungal activity against pathogenic microbes S. aureus ATCC25923, E. coli ATCC25922 and fungi C. albicans ATCC885-653 was determined for some representatives of the compounds series. Since the evaluated acute toxicity of the compounds is quite low, they can be recommended for further systematic investigation as possible prospective disinfection agents for food industry.Vitaliy CHORNOUSAlina GROZAVVictoria ANTONIYCHUKNina YAKOVYCHUKMykhaylo VOVKStefan cel Mare University of Suceavaarticleorganic synthesisimidazolesthiazolidinonesantimicrobial and antifungal activityfoodstuff treat-ment and productionFood processing and manufactureTP368-456ENFood and Environment Safety, Vol 18, Iss 1, Pp 13-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	organic synthesis imidazoles thiazolidinones antimicrobial and antifungal activity foodstuff treat-ment and production Food processing and manufacture TP368-456
spellingShingle	organic synthesis imidazoles thiazolidinones antimicrobial and antifungal activity foodstuff treat-ment and production Food processing and manufacture TP368-456 Vitaliy CHORNOUS Alina GROZAV Victoria ANTONIYCHUK Nina YAKOVYCHUK Mykhaylo VOVK (IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY
description	An antimicrobial and antifungal activity of new derivatives of (imidazole-5-yl)ylidenthiazolidinones and its dependence on the substance structure and the type of substitutes in the imidazole and thiazole nucleus have been investigated. It was found that the sulphur of thiazolidone section is the key factor that governs antimicrobial activity of the compounds. High antibacterial and antifungal activity against pathogenic microbes S. aureus ATCC25923, E. coli ATCC25922 and fungi C. albicans ATCC885-653 was determined for some representatives of the compounds series. Since the evaluated acute toxicity of the compounds is quite low, they can be recommended for further systematic investigation as possible prospective disinfection agents for food industry.
format	article
author	Vitaliy CHORNOUS Alina GROZAV Victoria ANTONIYCHUK Nina YAKOVYCHUK Mykhaylo VOVK
author_facet	Vitaliy CHORNOUS Alina GROZAV Victoria ANTONIYCHUK Nina YAKOVYCHUK Mykhaylo VOVK
author_sort	Vitaliy CHORNOUS
title	(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY
title_short	(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY
title_full	(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY
title_fullStr	(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY
title_full_unstemmed	(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY
title_sort	(imidazole-5-yl)ylidenthiazolidones: a new class of antimicrobial agents for food industry
publisher	Stefan cel Mare University of Suceava
publishDate	2019
url	https://doaj.org/article/b3e7fa911695453caa0703bc4eb23251
work_keys_str_mv	AT vitaliychornous imidazole5ylylidenthiazolidonesanewclassofantimicrobialagentsforfoodindustry AT alinagrozav imidazole5ylylidenthiazolidonesanewclassofantimicrobialagentsforfoodindustry AT victoriaantoniychuk imidazole5ylylidenthiazolidonesanewclassofantimicrobialagentsforfoodindustry AT ninayakovychuk imidazole5ylylidenthiazolidonesanewclassofantimicrobialagentsforfoodindustry AT mykhaylovovk imidazole5ylylidenthiazolidonesanewclassofantimicrobialagentsforfoodindustry
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(IMIDAZOLE-5-YL)YLIDENTHIAZOLIDONES: A NEW CLASS OF ANTIMICROBIAL AGENTS FOR FOOD INDUSTRY

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