Polymer-Based Nanosystems—A Versatile Delivery Approach

Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can re...

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Autores principales:	Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polymer-based nanoparticles drug delivery targeted delivery vaccine delivery vaccine adjuvants novel nanocarriers Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/b3e7fbffd5e04f428dea832496dd5a2c
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spelling	oai:doaj.org-article:b3e7fbffd5e04f428dea832496dd5a2c2021-11-25T18:13:46ZPolymer-Based Nanosystems—A Versatile Delivery Approach10.3390/ma142268121996-1944https://doaj.org/article/b3e7fbffd5e04f428dea832496dd5a2c2021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6812https://doaj.org/toc/1996-1944Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.Adelina-Gabriela NiculescuAlexandru Mihai GrumezescuMDPI AGarticlepolymer-based nanoparticlesdrug deliverytargeted deliveryvaccine deliveryvaccine adjuvantsnovel nanocarriersTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6812, p 6812 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymer-based nanoparticles drug delivery targeted delivery vaccine delivery vaccine adjuvants novel nanocarriers Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	polymer-based nanoparticles drug delivery targeted delivery vaccine delivery vaccine adjuvants novel nanocarriers Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Adelina-Gabriela Niculescu Alexandru Mihai Grumezescu Polymer-Based Nanosystems—A Versatile Delivery Approach
description	Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.
format	article
author	Adelina-Gabriela Niculescu Alexandru Mihai Grumezescu
author_facet	Adelina-Gabriela Niculescu Alexandru Mihai Grumezescu
author_sort	Adelina-Gabriela Niculescu
title	Polymer-Based Nanosystems—A Versatile Delivery Approach
title_short	Polymer-Based Nanosystems—A Versatile Delivery Approach
title_full	Polymer-Based Nanosystems—A Versatile Delivery Approach
title_fullStr	Polymer-Based Nanosystems—A Versatile Delivery Approach
title_full_unstemmed	Polymer-Based Nanosystems—A Versatile Delivery Approach
title_sort	polymer-based nanosystems—a versatile delivery approach
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b3e7fbffd5e04f428dea832496dd5a2c
work_keys_str_mv	AT adelinagabrielaniculescu polymerbasednanosystemsaversatiledeliveryapproach AT alexandrumihaigrumezescu polymerbasednanosystemsaversatiledeliveryapproach
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Polymer-Based Nanosystems—A Versatile Delivery Approach

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