Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths

Abstract High baseline atherogenic lipid level has been an established risk factor for the risk of cardiovascular events. Evidence concerning the role of lipid changes in cardiovascular and death risks are inconclusive. A cohort study was conducted based on the Taiwanese Survey on Hypertension, Hype...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hsin-Yin Hsu, Ming-Chieh Tsai, Tzu-Lin Yeh, Le-Yin Hsu, Lee-Ching Hwang, Kuo-Liong Chien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3edcee822c1400790af434c3d29ec5c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b3edcee822c1400790af434c3d29ec5c
record_format	dspace
spelling	oai:doaj.org-article:b3edcee822c1400790af434c3d29ec5c2021-12-02T13:26:50ZAssociation of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths10.1038/s41598-021-86336-62045-2322https://doaj.org/article/b3edcee822c1400790af434c3d29ec5c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86336-6https://doaj.org/toc/2045-2322Abstract High baseline atherogenic lipid level has been an established risk factor for the risk of cardiovascular events. Evidence concerning the role of lipid changes in cardiovascular and death risks are inconclusive. A cohort study was conducted based on the Taiwanese Survey on Hypertension, Hyperglycemia, and Hyperlipidemia (n = 4072, mean 44.8 years, 53.5% women) assessing lipid levels of the participants repeatedly measured in 2002 and 2007. Combined baseline and changes in lipid levels were classified into four groups—stable or decreasing lipid changes and increasing lipid changes with low- and high-risk baseline lipid levels. Developing cardiovascular events (n = 225) and all-cause deaths (n = 345) were ascertained during a median follow-up of 13.3 years. Participants with increasing and higher total cholesterol level were more likely to develop cardiovascular risks. Similar patterns for cardiovascular events were observed across other lipid profile changes. However, participants with increasing total cholesterol, LDL-C, and non-high-density lipoprotein cholesterol (non-HDL-C) levels were more likely to be at a lower risk for all-cause deaths. Baseline and changes in total cholesterol, triglycerides, and LDL-C levels were positively associated with the risk of cardiovascular diseases, whereas baseline and changes in total cholesterol and LDL-C and non-HDL-C levels were inversely associated with all-cause deaths.Hsin-Yin HsuMing-Chieh TsaiTzu-Lin YehLe-Yin HsuLee-Ching HwangKuo-Liong ChienNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsin-Yin Hsu Ming-Chieh Tsai Tzu-Lin Yeh Le-Yin Hsu Lee-Ching Hwang Kuo-Liong Chien Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths
description	Abstract High baseline atherogenic lipid level has been an established risk factor for the risk of cardiovascular events. Evidence concerning the role of lipid changes in cardiovascular and death risks are inconclusive. A cohort study was conducted based on the Taiwanese Survey on Hypertension, Hyperglycemia, and Hyperlipidemia (n = 4072, mean 44.8 years, 53.5% women) assessing lipid levels of the participants repeatedly measured in 2002 and 2007. Combined baseline and changes in lipid levels were classified into four groups—stable or decreasing lipid changes and increasing lipid changes with low- and high-risk baseline lipid levels. Developing cardiovascular events (n = 225) and all-cause deaths (n = 345) were ascertained during a median follow-up of 13.3 years. Participants with increasing and higher total cholesterol level were more likely to develop cardiovascular risks. Similar patterns for cardiovascular events were observed across other lipid profile changes. However, participants with increasing total cholesterol, LDL-C, and non-high-density lipoprotein cholesterol (non-HDL-C) levels were more likely to be at a lower risk for all-cause deaths. Baseline and changes in total cholesterol, triglycerides, and LDL-C levels were positively associated with the risk of cardiovascular diseases, whereas baseline and changes in total cholesterol and LDL-C and non-HDL-C levels were inversely associated with all-cause deaths.
format	article
author	Hsin-Yin Hsu Ming-Chieh Tsai Tzu-Lin Yeh Le-Yin Hsu Lee-Ching Hwang Kuo-Liong Chien
author_facet	Hsin-Yin Hsu Ming-Chieh Tsai Tzu-Lin Yeh Le-Yin Hsu Lee-Ching Hwang Kuo-Liong Chien
author_sort	Hsin-Yin Hsu
title	Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths
title_short	Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths
title_full	Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths
title_fullStr	Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths
title_full_unstemmed	Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths
title_sort	association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3edcee822c1400790af434c3d29ec5c
work_keys_str_mv	AT hsinyinhsu associationofbaselineaswellaschangeinlipidlevelswiththeriskofcardiovasculardiseasesandallcausedeaths AT mingchiehtsai associationofbaselineaswellaschangeinlipidlevelswiththeriskofcardiovasculardiseasesandallcausedeaths AT tzulinyeh associationofbaselineaswellaschangeinlipidlevelswiththeriskofcardiovasculardiseasesandallcausedeaths AT leyinhsu associationofbaselineaswellaschangeinlipidlevelswiththeriskofcardiovasculardiseasesandallcausedeaths AT leechinghwang associationofbaselineaswellaschangeinlipidlevelswiththeriskofcardiovasculardiseasesandallcausedeaths AT kuoliongchien associationofbaselineaswellaschangeinlipidlevelswiththeriskofcardiovasculardiseasesandallcausedeaths
_version_	1718393053592420352

Association of baseline as well as change in lipid levels with the risk of cardiovascular diseases and all-cause deaths

Ejemplares similares