A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment

Abstract T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), an immune checkpoint, plays a pivotal role in immune suppression. However its role in tumor immunity and correlation with the genetic and epigenetic alterations remains unknown. Here, we comprehensively analyzed the expressi...

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Autores principales:	Jie Wen, Xueyi Mao, Quan Cheng, Zhixiong Liu, Fangkun Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3ee040edf3240308e4e564a6fe8b971
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spelling	oai:doaj.org-article:b3ee040edf3240308e4e564a6fe8b9712021-11-21T12:16:44ZA pan-cancer analysis revealing the role of TIGIT in tumor microenvironment10.1038/s41598-021-01933-92045-2322https://doaj.org/article/b3ee040edf3240308e4e564a6fe8b9712021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01933-9https://doaj.org/toc/2045-2322Abstract T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), an immune checkpoint, plays a pivotal role in immune suppression. However its role in tumor immunity and correlation with the genetic and epigenetic alterations remains unknown. Here, we comprehensively analyzed the expression patterns of the TIGIT and its value of prognostic prediction among 33 types of cancers based on the data collected from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression projects (GTEx). Furthermore, the correlations of TIGIT with pathological stages, tumor-infiltrating immune cells (TIICs), signatures of T cells subtypes, immune checkpoint genes, the degree of Estimation of STromal and Immune cells in MAlignant Tumor tissues using the Expression data (ESTIMATE), tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR) genes, and DNA methyltransferases (DNMTs) were also explored. Gene functional enrichment was conducted by Gene Set Enrichment Analysis (GSEA). Our results showed that the expression of TIGIT was upregulated in most of the cancer types. Cox regression model showed that high expression of TIGIT in tumor samples correlates with poor prognosis in KIRC, KIRP, LGG, UVM, and with favorable prognosis in BRCA, CECS, HNSC, SKCM. TIGIT expression positively correlated with advanced stages, TIICs, the signatures of effector T cells, exhausted T cells, effector Tregs and the degree of ESTIMATE in KIRC, KIRP and UVM. TIGIT expression also positively correlated with CTLA4, PDCD1 (PD-1), CD274 (PD-L1), ICOS in most of the cancer types. Furthermore, the expression of TIGIT was correlated with TMB, MSI, MMR genes and DNMTs in different types of cancers. GSEA analysis showed that the expression of TIGIT was related to cytokine-cytokine receptor interaction, allograft rejection, oxidative phosphorylation. These findings suggested that TIGIT could serve as a potential biomarker for prognosis and a novel target for immunotherapies in cancers.Jie WenXueyi MaoQuan ChengZhixiong LiuFangkun LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie Wen Xueyi Mao Quan Cheng Zhixiong Liu Fangkun Liu A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
description	Abstract T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), an immune checkpoint, plays a pivotal role in immune suppression. However its role in tumor immunity and correlation with the genetic and epigenetic alterations remains unknown. Here, we comprehensively analyzed the expression patterns of the TIGIT and its value of prognostic prediction among 33 types of cancers based on the data collected from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression projects (GTEx). Furthermore, the correlations of TIGIT with pathological stages, tumor-infiltrating immune cells (TIICs), signatures of T cells subtypes, immune checkpoint genes, the degree of Estimation of STromal and Immune cells in MAlignant Tumor tissues using the Expression data (ESTIMATE), tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR) genes, and DNA methyltransferases (DNMTs) were also explored. Gene functional enrichment was conducted by Gene Set Enrichment Analysis (GSEA). Our results showed that the expression of TIGIT was upregulated in most of the cancer types. Cox regression model showed that high expression of TIGIT in tumor samples correlates with poor prognosis in KIRC, KIRP, LGG, UVM, and with favorable prognosis in BRCA, CECS, HNSC, SKCM. TIGIT expression positively correlated with advanced stages, TIICs, the signatures of effector T cells, exhausted T cells, effector Tregs and the degree of ESTIMATE in KIRC, KIRP and UVM. TIGIT expression also positively correlated with CTLA4, PDCD1 (PD-1), CD274 (PD-L1), ICOS in most of the cancer types. Furthermore, the expression of TIGIT was correlated with TMB, MSI, MMR genes and DNMTs in different types of cancers. GSEA analysis showed that the expression of TIGIT was related to cytokine-cytokine receptor interaction, allograft rejection, oxidative phosphorylation. These findings suggested that TIGIT could serve as a potential biomarker for prognosis and a novel target for immunotherapies in cancers.
format	article
author	Jie Wen Xueyi Mao Quan Cheng Zhixiong Liu Fangkun Liu
author_facet	Jie Wen Xueyi Mao Quan Cheng Zhixiong Liu Fangkun Liu
author_sort	Jie Wen
title	A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
title_short	A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
title_full	A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
title_fullStr	A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
title_full_unstemmed	A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
title_sort	pan-cancer analysis revealing the role of tigit in tumor microenvironment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3ee040edf3240308e4e564a6fe8b971
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A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment

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