A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases

A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases

Abstract DNA-Damage Response (DDR) proteins are crucial for maintaining the integrity of the genome by identifying and repairing errors in DNA. Variants affecting their function can have severe consequences since failure to repair damaged DNA can result in cells turning cancerous. Here, we compare g...

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Autores principales: Lorena Magraner-Pardo, Roman A. Laskowski, Tirso Pons, Janet M. Thornton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/b3eee09f8ac742dab50ee895bf220e71
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