Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Cancer cell clusters metastasize to distant organ by polyclonal manner. Here, the authors show that malignant subclone induces fibrotic niche generation in the liver by hepatic stellate cell activation, supporting survival and colonization of non-metastatic cells to develop polyclonal metastasis.

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Autores principales:	Sau Yee Kok, Hiroko Oshima, Kei Takahashi, Mizuho Nakayama, Kazuhiro Murakami, Hiroki R. Ueda, Kohei Miyazono, Masanobu Oshima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3ef91d200aa418b81c3ad6199d1248d
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spelling	oai:doaj.org-article:b3ef91d200aa418b81c3ad6199d1248d2021-12-02T13:30:15ZMalignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation10.1038/s41467-021-21160-02041-1723https://doaj.org/article/b3ef91d200aa418b81c3ad6199d1248d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21160-0https://doaj.org/toc/2041-1723Cancer cell clusters metastasize to distant organ by polyclonal manner. Here, the authors show that malignant subclone induces fibrotic niche generation in the liver by hepatic stellate cell activation, supporting survival and colonization of non-metastatic cells to develop polyclonal metastasis.Sau Yee KokHiroko OshimaKei TakahashiMizuho NakayamaKazuhiro MurakamiHiroki R. UedaKohei MiyazonoMasanobu OshimaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sau Yee Kok Hiroko Oshima Kei Takahashi Mizuho Nakayama Kazuhiro Murakami Hiroki R. Ueda Kohei Miyazono Masanobu Oshima Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
description	Cancer cell clusters metastasize to distant organ by polyclonal manner. Here, the authors show that malignant subclone induces fibrotic niche generation in the liver by hepatic stellate cell activation, supporting survival and colonization of non-metastatic cells to develop polyclonal metastasis.
format	article
author	Sau Yee Kok Hiroko Oshima Kei Takahashi Mizuho Nakayama Kazuhiro Murakami Hiroki R. Ueda Kohei Miyazono Masanobu Oshima
author_facet	Sau Yee Kok Hiroko Oshima Kei Takahashi Mizuho Nakayama Kazuhiro Murakami Hiroki R. Ueda Kohei Miyazono Masanobu Oshima
author_sort	Sau Yee Kok
title	Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
title_short	Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
title_full	Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
title_fullStr	Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
title_full_unstemmed	Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
title_sort	malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3ef91d200aa418b81c3ad6199d1248d
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Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

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