Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.

Periodic auditory click stimulation has been reported to elicit an auditory steady state response (ASSR). The ASSR has been suggested to reflect the efficiency of γ-amino butyric acid (GABA) inhibitory interneuronal activity. Although a potential role for GABAergic dysfunction has been previously pr...

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Autores principales:	Yuko Oda, Toshiaki Onitsuka, Rikako Tsuchimoto, Shogo Hirano, Naoya Oribe, Takefumi Ueno, Yoji Hirano, Itta Nakamura, Tomofumi Miura, Shigenobu Kanba
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3f0b04bf5b1436dbf4585fe6f15ecb7
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spelling	oai:doaj.org-article:b3f0b04bf5b1436dbf4585fe6f15ecb72021-11-18T07:13:24ZGamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.1932-620310.1371/journal.pone.0039955https://doaj.org/article/b3f0b04bf5b1436dbf4585fe6f15ecb72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792199/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Periodic auditory click stimulation has been reported to elicit an auditory steady state response (ASSR). The ASSR has been suggested to reflect the efficiency of γ-amino butyric acid (GABA) inhibitory interneuronal activity. Although a potential role for GABAergic dysfunction has been previously proposed, the role of neural synchronization in the ASSR in people with bipolar disorder (BD) has received little attention. In the current study, we investigated ASSRs to 20 Hz, 30 Hz, 40 Hz and 80 Hz click trains in BD patients. A total of 14 (4 males) BD patients and 25 (10 males) healthy controls participated in this study. ASSRs were obtained using whole-head 306-channel magnetoencephalography to calculate, ASSR power values and phase locking factors (PLF). BD patients exhibited significantly reduced mean ASSR power and PLF values bilaterally at frequencies of 30, 40, and 80 Hz (p<0.05 for these frequencies). At 20 Hz, bipolar patients showed no significant reduction in mean ASSR power and PLF values. There was a significant negative correlation between 80 Hz-ASSR-power values obtained from the right hemisphere and scores on the Hamilton Depression Rating Scale (rho = -0.86, p = 0.0003). The current study showed reduced low and high gamma band ASSR power and PLF bilaterally with no significant beta band ASSR reduction in BD patients. BD patients are characterized by deficits in gamma band oscillations, which may be associated with GABA inhibitory interneuronal activity dysfunction.Yuko OdaToshiaki OnitsukaRikako TsuchimotoShogo HiranoNaoya OribeTakefumi UenoYoji HiranoItta NakamuraTomofumi MiuraShigenobu KanbaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e39955 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Oda Toshiaki Onitsuka Rikako Tsuchimoto Shogo Hirano Naoya Oribe Takefumi Ueno Yoji Hirano Itta Nakamura Tomofumi Miura Shigenobu Kanba Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
description	Periodic auditory click stimulation has been reported to elicit an auditory steady state response (ASSR). The ASSR has been suggested to reflect the efficiency of γ-amino butyric acid (GABA) inhibitory interneuronal activity. Although a potential role for GABAergic dysfunction has been previously proposed, the role of neural synchronization in the ASSR in people with bipolar disorder (BD) has received little attention. In the current study, we investigated ASSRs to 20 Hz, 30 Hz, 40 Hz and 80 Hz click trains in BD patients. A total of 14 (4 males) BD patients and 25 (10 males) healthy controls participated in this study. ASSRs were obtained using whole-head 306-channel magnetoencephalography to calculate, ASSR power values and phase locking factors (PLF). BD patients exhibited significantly reduced mean ASSR power and PLF values bilaterally at frequencies of 30, 40, and 80 Hz (p<0.05 for these frequencies). At 20 Hz, bipolar patients showed no significant reduction in mean ASSR power and PLF values. There was a significant negative correlation between 80 Hz-ASSR-power values obtained from the right hemisphere and scores on the Hamilton Depression Rating Scale (rho = -0.86, p = 0.0003). The current study showed reduced low and high gamma band ASSR power and PLF bilaterally with no significant beta band ASSR reduction in BD patients. BD patients are characterized by deficits in gamma band oscillations, which may be associated with GABA inhibitory interneuronal activity dysfunction.
format	article
author	Yuko Oda Toshiaki Onitsuka Rikako Tsuchimoto Shogo Hirano Naoya Oribe Takefumi Ueno Yoji Hirano Itta Nakamura Tomofumi Miura Shigenobu Kanba
author_facet	Yuko Oda Toshiaki Onitsuka Rikako Tsuchimoto Shogo Hirano Naoya Oribe Takefumi Ueno Yoji Hirano Itta Nakamura Tomofumi Miura Shigenobu Kanba
author_sort	Yuko Oda
title	Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
title_short	Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
title_full	Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
title_fullStr	Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
title_full_unstemmed	Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
title_sort	gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b3f0b04bf5b1436dbf4585fe6f15ecb7
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Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients.

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