Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications

MRI contrast agents containing the rare earth metal gadolinium are very effective, yet unstable and thus potentially hazardous. Here, the authors developed complexes between gadolinium and the scaffolding compound DOTA with increased stability, which also lend themselves to radiometal labelling.

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Autores principales:	Lixiong Dai, Chloe M. Jones, Wesley Ting Kwok Chan, Tiffany A. Pham, Xiaoxi Ling, Eric M. Gale, Nicholas J. Rotile, William Chi-Shing Tai, Carolyn J. Anderson, Peter Caravan, Ga-Lai Law
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b3f0ee3971b54efaad568f148589af0b
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spelling	oai:doaj.org-article:b3f0ee3971b54efaad568f148589af0b2021-12-02T15:33:42ZChiral DOTA chelators as an improved platform for biomedical imaging and therapy applications10.1038/s41467-018-03315-82041-1723https://doaj.org/article/b3f0ee3971b54efaad568f148589af0b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03315-8https://doaj.org/toc/2041-1723MRI contrast agents containing the rare earth metal gadolinium are very effective, yet unstable and thus potentially hazardous. Here, the authors developed complexes between gadolinium and the scaffolding compound DOTA with increased stability, which also lend themselves to radiometal labelling.Lixiong DaiChloe M. JonesWesley Ting Kwok ChanTiffany A. PhamXiaoxi LingEric M. GaleNicholas J. RotileWilliam Chi-Shing TaiCarolyn J. AndersonPeter CaravanGa-Lai LawNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lixiong Dai Chloe M. Jones Wesley Ting Kwok Chan Tiffany A. Pham Xiaoxi Ling Eric M. Gale Nicholas J. Rotile William Chi-Shing Tai Carolyn J. Anderson Peter Caravan Ga-Lai Law Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications
description	MRI contrast agents containing the rare earth metal gadolinium are very effective, yet unstable and thus potentially hazardous. Here, the authors developed complexes between gadolinium and the scaffolding compound DOTA with increased stability, which also lend themselves to radiometal labelling.
format	article
author	Lixiong Dai Chloe M. Jones Wesley Ting Kwok Chan Tiffany A. Pham Xiaoxi Ling Eric M. Gale Nicholas J. Rotile William Chi-Shing Tai Carolyn J. Anderson Peter Caravan Ga-Lai Law
author_facet	Lixiong Dai Chloe M. Jones Wesley Ting Kwok Chan Tiffany A. Pham Xiaoxi Ling Eric M. Gale Nicholas J. Rotile William Chi-Shing Tai Carolyn J. Anderson Peter Caravan Ga-Lai Law
author_sort	Lixiong Dai
title	Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications
title_short	Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications
title_full	Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications
title_fullStr	Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications
title_full_unstemmed	Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications
title_sort	chiral dota chelators as an improved platform for biomedical imaging and therapy applications
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b3f0ee3971b54efaad568f148589af0b
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Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications

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