The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample

Background: Oxidative stress markers are found to be linked with depression and suicide attempts in bipolar disorder (BD), although the role of DNA damage as a marker of suicidal ideation and attempt has yet to be determined. We aim to investigate the association between DNA damage and suicidal beha...

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Autores principales:	Jiann Lin Loo, Nurul Ain Mohamad Kamal, Jo Aan Goon, Hanafi Ahmad Damanhuri, Jaclyn Ai Chin Tan, Nor Azian Abdul Murad, Shamsul Azhar Shah, Siti Aishah Sulaiman, Shazrul Fazry, Shalisah Sharip, Suriati Mohamed Saini, Geetha Gunasekaran, Thambu Maniam, A. Rahman A. Jamal, Wan Zurinah Wan Ngah, Fatimatul Syahirah Mohd Badli Shah, Lai Fong Chan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	suicidal ideation suicide attempt suicide suicidal behaviour oxidative stress biomarkers Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/b3f2e42687bb41779a06e6ba3d6c133f
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spelling	oai:doaj.org-article:b3f2e42687bb41779a06e6ba3d6c133f2021-12-01T16:29:59ZThe Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample1664-064010.3389/fpsyt.2021.698911https://doaj.org/article/b3f2e42687bb41779a06e6ba3d6c133f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.698911/fullhttps://doaj.org/toc/1664-0640Background: Oxidative stress markers are found to be linked with depression and suicide attempts in bipolar disorder (BD), although the role of DNA damage as a marker of suicidal ideation and attempt has yet to be determined. We aim to investigate the association between DNA damage and suicidal behaviour, i.e., suicidal ideation and suicide attempt, among suicidal ideators in BD patients while accounting for clinical and psychosocial risk factors.Methods: A cross-sectional study was conducted in the Universiti Kebangsaan Malaysia Medical Centre on 62 consecutive BD patients diagnosed using the M.I.N.I. Neuropsychiatric Interview and 26 healthy control participants. Socio-demographic and clinical assessments were performed using the Columbia Suicide Severity Rating Scale (C-SSRS) for lifetime suicidal ideation and attempt, Quick Inventory of Depressive Symptomatology (QIDS) for depression severity, Clinical Global Impression for Bipolar Disorder (CGI-BD) for illness severity [both mania (CGI-Mania) and major depressive episode (CGI-MDE)], Social Readjustment Rating Scale (SRRS) for change in life events, and Barratt Impulsiveness Scale (BIS) for behavioural impulsivity. The degree of DNA damage in peripheral blood samples was determined using a standard protocol of comet assay.Results: Multivariable logistic regression revealed higher scores of CGI-MDE as the sole significant factor for lifetime suicidal ideation (OR = 1.937, 95% CI = 1.799–2.076). Although initial bivariate analysis showed a significant association between DNA damage, malondialdehyde (MDA), catalase (CAT), and suicidal behaviour, the findings were not seen in multivariable logistic regression. Bivariate subgroup analysis showed that moderate and severe DNA damage (p = 0.032 and p = 0.047, respectively) was significantly associated with lifetime suicide attempts among lifetime suicidal ideators. The study is the first to look at the connexion between DNA damage and suicidal risk in bipolar patients. It is limited by the small sample size and lack of information on illicit substance use.Conclusions: More severe DNA damage was significantly associated with lifetime suicide attempts among lifetime suicidal ideators in BD. However, the severity of depression was found to be independently associated with lifetime suicidal ideation per se rather than DNA damage in BD. Larger prospective studies are required to ascertain the potential of DNA damage as a biomarker for the transition from suicidal ideation to a suicide attempt.Jiann Lin LooJiann Lin LooNurul Ain Mohamad KamalJo Aan GoonHanafi Ahmad DamanhuriJaclyn Ai Chin TanNor Azian Abdul MuradShamsul Azhar ShahSiti Aishah SulaimanShazrul FazryShalisah SharipSuriati Mohamed SainiGeetha GunasekaranThambu ManiamA. Rahman A. JamalWan Zurinah Wan NgahFatimatul Syahirah Mohd Badli ShahLai Fong ChanFrontiers Media S.A.articlesuicidal ideationsuicide attemptsuicidesuicidal behaviouroxidative stressbiomarkersPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	suicidal ideation suicide attempt suicide suicidal behaviour oxidative stress biomarkers Psychiatry RC435-571
spellingShingle	suicidal ideation suicide attempt suicide suicidal behaviour oxidative stress biomarkers Psychiatry RC435-571 Jiann Lin Loo Jiann Lin Loo Nurul Ain Mohamad Kamal Jo Aan Goon Hanafi Ahmad Damanhuri Jaclyn Ai Chin Tan Nor Azian Abdul Murad Shamsul Azhar Shah Siti Aishah Sulaiman Shazrul Fazry Shalisah Sharip Suriati Mohamed Saini Geetha Gunasekaran Thambu Maniam A. Rahman A. Jamal Wan Zurinah Wan Ngah Fatimatul Syahirah Mohd Badli Shah Lai Fong Chan The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample
description	Background: Oxidative stress markers are found to be linked with depression and suicide attempts in bipolar disorder (BD), although the role of DNA damage as a marker of suicidal ideation and attempt has yet to be determined. We aim to investigate the association between DNA damage and suicidal behaviour, i.e., suicidal ideation and suicide attempt, among suicidal ideators in BD patients while accounting for clinical and psychosocial risk factors.Methods: A cross-sectional study was conducted in the Universiti Kebangsaan Malaysia Medical Centre on 62 consecutive BD patients diagnosed using the M.I.N.I. Neuropsychiatric Interview and 26 healthy control participants. Socio-demographic and clinical assessments were performed using the Columbia Suicide Severity Rating Scale (C-SSRS) for lifetime suicidal ideation and attempt, Quick Inventory of Depressive Symptomatology (QIDS) for depression severity, Clinical Global Impression for Bipolar Disorder (CGI-BD) for illness severity [both mania (CGI-Mania) and major depressive episode (CGI-MDE)], Social Readjustment Rating Scale (SRRS) for change in life events, and Barratt Impulsiveness Scale (BIS) for behavioural impulsivity. The degree of DNA damage in peripheral blood samples was determined using a standard protocol of comet assay.Results: Multivariable logistic regression revealed higher scores of CGI-MDE as the sole significant factor for lifetime suicidal ideation (OR = 1.937, 95% CI = 1.799–2.076). Although initial bivariate analysis showed a significant association between DNA damage, malondialdehyde (MDA), catalase (CAT), and suicidal behaviour, the findings were not seen in multivariable logistic regression. Bivariate subgroup analysis showed that moderate and severe DNA damage (p = 0.032 and p = 0.047, respectively) was significantly associated with lifetime suicide attempts among lifetime suicidal ideators. The study is the first to look at the connexion between DNA damage and suicidal risk in bipolar patients. It is limited by the small sample size and lack of information on illicit substance use.Conclusions: More severe DNA damage was significantly associated with lifetime suicide attempts among lifetime suicidal ideators in BD. However, the severity of depression was found to be independently associated with lifetime suicidal ideation per se rather than DNA damage in BD. Larger prospective studies are required to ascertain the potential of DNA damage as a biomarker for the transition from suicidal ideation to a suicide attempt.
format	article
author	Jiann Lin Loo Jiann Lin Loo Nurul Ain Mohamad Kamal Jo Aan Goon Hanafi Ahmad Damanhuri Jaclyn Ai Chin Tan Nor Azian Abdul Murad Shamsul Azhar Shah Siti Aishah Sulaiman Shazrul Fazry Shalisah Sharip Suriati Mohamed Saini Geetha Gunasekaran Thambu Maniam A. Rahman A. Jamal Wan Zurinah Wan Ngah Fatimatul Syahirah Mohd Badli Shah Lai Fong Chan
author_facet	Jiann Lin Loo Jiann Lin Loo Nurul Ain Mohamad Kamal Jo Aan Goon Hanafi Ahmad Damanhuri Jaclyn Ai Chin Tan Nor Azian Abdul Murad Shamsul Azhar Shah Siti Aishah Sulaiman Shazrul Fazry Shalisah Sharip Suriati Mohamed Saini Geetha Gunasekaran Thambu Maniam A. Rahman A. Jamal Wan Zurinah Wan Ngah Fatimatul Syahirah Mohd Badli Shah Lai Fong Chan
author_sort	Jiann Lin Loo
title	The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample
title_short	The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample
title_full	The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample
title_fullStr	The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample
title_full_unstemmed	The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample
title_sort	role of oxidative stress in suicidal behaviour among bipolar patients: a cross-sectional study in a malaysian sample
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b3f2e42687bb41779a06e6ba3d6c133f
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The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample

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