Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management

The prevalence of asthma is increasing, but the cause remains under debate. Research currently focuses on environmental and dietary factors that may impact the gut-lung axis. Dietary fibers are considered to play a crucial role in supporting diversity and activity of the microbiome, as well as immun...

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Autores principales:	Roos E. M. Verstegen, Atanaska I. Kostadinova, Zenebech Merenciana, Johan Garssen, Gert Folkerts, Rudi W. Hendriks, Linette E. M. Willemsen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	allergic asthma gut-lung axis microbiota fermentable fibers short-chain fatty acids immunity Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b3fba412b7014d12b59a1a5a897095d0
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spelling	oai:doaj.org-article:b3fba412b7014d12b59a1a5a897095d02021-11-25T18:37:10ZDietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management10.3390/nu131141532072-6643https://doaj.org/article/b3fba412b7014d12b59a1a5a897095d02021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4153https://doaj.org/toc/2072-6643The prevalence of asthma is increasing, but the cause remains under debate. Research currently focuses on environmental and dietary factors that may impact the gut-lung axis. Dietary fibers are considered to play a crucial role in supporting diversity and activity of the microbiome, as well as immune homeostasis in the gut and lung. This review discusses the current state of knowledge on how dietary fibers and their bacterial fermentation products may affect the pathophysiology of allergic asthma. Moreover, the impact of dietary fibers on early type 2 asthma management, as shown in both pre-clinical and clinical studies, is described. Short-chain fatty acids, fiber metabolites, modulate host immunity and might reduce the risk of allergic asthma development. Underlying mechanisms include G protein-coupled receptor activation and histone deacetylase inhibition. These results are supported by studies in mice, children and adults with allergic asthma. Fibers might also exert direct effects on the immune system via yet to be elucidated mechanisms. However, the effects of specific types of fiber, dosages, duration of treatment, and combination with probiotics, need to be explored. There is an urgent need to further valorize the potential of specific dietary fibers in prevention and treatment of allergic asthma by conducting more large-scale dietary intervention trials.Roos E. M. VerstegenAtanaska I. KostadinovaZenebech MerencianaJohan GarssenGert FolkertsRudi W. HendriksLinette E. M. WillemsenMDPI AGarticleallergic asthmagut-lung axismicrobiotafermentable fibersshort-chain fatty acidsimmunityNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4153, p 4153 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	allergic asthma gut-lung axis microbiota fermentable fibers short-chain fatty acids immunity Nutrition. Foods and food supply TX341-641
spellingShingle	allergic asthma gut-lung axis microbiota fermentable fibers short-chain fatty acids immunity Nutrition. Foods and food supply TX341-641 Roos E. M. Verstegen Atanaska I. Kostadinova Zenebech Merenciana Johan Garssen Gert Folkerts Rudi W. Hendriks Linette E. M. Willemsen Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management
description	The prevalence of asthma is increasing, but the cause remains under debate. Research currently focuses on environmental and dietary factors that may impact the gut-lung axis. Dietary fibers are considered to play a crucial role in supporting diversity and activity of the microbiome, as well as immune homeostasis in the gut and lung. This review discusses the current state of knowledge on how dietary fibers and their bacterial fermentation products may affect the pathophysiology of allergic asthma. Moreover, the impact of dietary fibers on early type 2 asthma management, as shown in both pre-clinical and clinical studies, is described. Short-chain fatty acids, fiber metabolites, modulate host immunity and might reduce the risk of allergic asthma development. Underlying mechanisms include G protein-coupled receptor activation and histone deacetylase inhibition. These results are supported by studies in mice, children and adults with allergic asthma. Fibers might also exert direct effects on the immune system via yet to be elucidated mechanisms. However, the effects of specific types of fiber, dosages, duration of treatment, and combination with probiotics, need to be explored. There is an urgent need to further valorize the potential of specific dietary fibers in prevention and treatment of allergic asthma by conducting more large-scale dietary intervention trials.
format	article
author	Roos E. M. Verstegen Atanaska I. Kostadinova Zenebech Merenciana Johan Garssen Gert Folkerts Rudi W. Hendriks Linette E. M. Willemsen
author_facet	Roos E. M. Verstegen Atanaska I. Kostadinova Zenebech Merenciana Johan Garssen Gert Folkerts Rudi W. Hendriks Linette E. M. Willemsen
author_sort	Roos E. M. Verstegen
title	Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management
title_short	Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management
title_full	Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management
title_fullStr	Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management
title_full_unstemmed	Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management
title_sort	dietary fibers: effects, underlying mechanisms and possible role in allergic asthma management
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b3fba412b7014d12b59a1a5a897095d0
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Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management

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