Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.

<h4>Background</h4>Familial Mediterranean fever (FMF) is an autoinflammatory condition, which is characterized by acute, self-limiting episodes of fever and serositis and chronic subclinical inflammation in remission. Here we investigated the consequence of this condition on the level of...

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Autores principales:	Gayane P Manukyan, Karine A Ghazaryan, Zhanna A Ktsoyan, Zaruhi A Khachatryan, Karine A Arakelova, Denise Kelly, George Grant, Rustam I Aminov
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3fcd9524ee74de0ba4007d499b8e758
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spelling	oai:doaj.org-article:b3fcd9524ee74de0ba4007d499b8e7582021-11-25T06:18:41ZElevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.1932-620310.1371/journal.pone.0003172https://doaj.org/article/b3fcd9524ee74de0ba4007d499b8e7582008-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18779861/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Familial Mediterranean fever (FMF) is an autoinflammatory condition, which is characterized by acute, self-limiting episodes of fever and serositis and chronic subclinical inflammation in remission. Here we investigated the consequence of this condition on the level of systemic antibodies directed towards common intestinal bacteria.<h4>Methodology/principal findings</h4>The level of systemic antibodies towards the antigens of Bacteroides, Parabacteroides, Escherichia, Enteroccocus and Lactobaccilus was measured by ELISA in FMF patients at various stages of the disease and in healthy controls. The difference between remission and attack was not significant. IgG antibodies against the antigens of Bacteroides, Parabacteroides, Escherichia and Enteroccocus were significantly increased in FMF compared to control while IgA levels were not significantly affected. Western blot analyses demonstrated the IgG reactivity against multiple antigens of commensal bacteria in FMF. Serological expression cloning was performed to identify these antigens. No single dominant antigen was identified; the response was generalized and directed against a variety of proteins from Bacteroides, Parabacteroides, Escherichia, and other gut commensals.<h4>Conclusions/significance</h4>This autoinflammatory syndrome is characterized by the increased systemic reactivity against commensal gut microbiota. This is probably the consequence of hypersensitivity of the inflammasome in FMF that triggers the inflammation and contributes to the excessive translocation of bacteria and bacterial antigens through the gut barrier.Gayane P ManukyanKarine A GhazaryanZhanna A KtsoyanZaruhi A KhachatryanKarine A ArakelovaDenise KellyGeorge GrantRustam I AminovPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 9, p e3172 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gayane P Manukyan Karine A Ghazaryan Zhanna A Ktsoyan Zaruhi A Khachatryan Karine A Arakelova Denise Kelly George Grant Rustam I Aminov Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
description	<h4>Background</h4>Familial Mediterranean fever (FMF) is an autoinflammatory condition, which is characterized by acute, self-limiting episodes of fever and serositis and chronic subclinical inflammation in remission. Here we investigated the consequence of this condition on the level of systemic antibodies directed towards common intestinal bacteria.<h4>Methodology/principal findings</h4>The level of systemic antibodies towards the antigens of Bacteroides, Parabacteroides, Escherichia, Enteroccocus and Lactobaccilus was measured by ELISA in FMF patients at various stages of the disease and in healthy controls. The difference between remission and attack was not significant. IgG antibodies against the antigens of Bacteroides, Parabacteroides, Escherichia and Enteroccocus were significantly increased in FMF compared to control while IgA levels were not significantly affected. Western blot analyses demonstrated the IgG reactivity against multiple antigens of commensal bacteria in FMF. Serological expression cloning was performed to identify these antigens. No single dominant antigen was identified; the response was generalized and directed against a variety of proteins from Bacteroides, Parabacteroides, Escherichia, and other gut commensals.<h4>Conclusions/significance</h4>This autoinflammatory syndrome is characterized by the increased systemic reactivity against commensal gut microbiota. This is probably the consequence of hypersensitivity of the inflammasome in FMF that triggers the inflammation and contributes to the excessive translocation of bacteria and bacterial antigens through the gut barrier.
format	article
author	Gayane P Manukyan Karine A Ghazaryan Zhanna A Ktsoyan Zaruhi A Khachatryan Karine A Arakelova Denise Kelly George Grant Rustam I Aminov
author_facet	Gayane P Manukyan Karine A Ghazaryan Zhanna A Ktsoyan Zaruhi A Khachatryan Karine A Arakelova Denise Kelly George Grant Rustam I Aminov
author_sort	Gayane P Manukyan
title	Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
title_short	Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
title_full	Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
title_fullStr	Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
title_full_unstemmed	Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
title_sort	elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/b3fcd9524ee74de0ba4007d499b8e758
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Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.

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