Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients

Abstract This study aimed to discuss association between serum Angiopoietin2 (Ang2) levels, Ang2 gene polymorphisms and systemic lupus erythematosus (SLE) susceptibility. It was carried out by 235 SLE, 342 other inflammatory autoimmune diseases patients and 380 healthy individuals. Serum Ang2 levels...

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Autores principales:	Jia-Min Wang, Wang-Dong Xu, Zhi-Chao Yuan, Qian Wu, Jie Zhou, An-Fang Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b3fd8e39a18b40d8940e06c931123aac
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spelling	oai:doaj.org-article:b3fd8e39a18b40d8940e06c931123aac2021-12-02T15:13:01ZSerum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients10.1038/s41598-020-79544-z2045-2322https://doaj.org/article/b3fd8e39a18b40d8940e06c931123aac2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79544-zhttps://doaj.org/toc/2045-2322Abstract This study aimed to discuss association between serum Angiopoietin2 (Ang2) levels, Ang2 gene polymorphisms and systemic lupus erythematosus (SLE) susceptibility. It was carried out by 235 SLE, 342 other inflammatory autoimmune diseases patients and 380 healthy individuals. Serum Ang2 levels was examinated by ELISA, and Ang2 rs12674822, rs1823375, rs1868554, rs2442598, rs3739390 and rs734701 polymorphisms were genotyped using KASP. Increased Ang2 concentrations in SLE patients were observed compared with healthy controls and patients with other inflammatory autoimmune diseases. For allelic contrast, except for rs1823375 (P = 0.058) and rs2442598 (P = 0.523), frequencies of alleles for other polymorphisms were significantly different between SLE patients and controls. Genotypes for rs12674822 (TT), rs1868554 (TT, TA and TT+TA), rs734701 (TT) were negatively correlated with SLE susceptibility (OR = 0.564 for rs12674822; OR = 0.572, OR = 0.625, OR = 0.607 for rs1868554; OR = 0.580 for rs734701). Patients carrying rs1868554 T allele and rs3739390 G allele were more likely to develop hematuria (P = 0.039; P = 0.003). The G allele frequencies of rs12674822 and rs2442598 were higher in SLE patients with proteinuria (P = 0.043; P = 0.043). GC genotype frequency of rs3739390 was higher in patients with ds-DNA (+) (P = 0.024). In summary, SLE had increased serum Ang2, which may be a potential biomarker, and the polymorphisms correlated with SLE.Jia-Min WangWang-Dong XuZhi-Chao YuanQian WuJie ZhouAn-Fang HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jia-Min Wang Wang-Dong Xu Zhi-Chao Yuan Qian Wu Jie Zhou An-Fang Huang Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients
description	Abstract This study aimed to discuss association between serum Angiopoietin2 (Ang2) levels, Ang2 gene polymorphisms and systemic lupus erythematosus (SLE) susceptibility. It was carried out by 235 SLE, 342 other inflammatory autoimmune diseases patients and 380 healthy individuals. Serum Ang2 levels was examinated by ELISA, and Ang2 rs12674822, rs1823375, rs1868554, rs2442598, rs3739390 and rs734701 polymorphisms were genotyped using KASP. Increased Ang2 concentrations in SLE patients were observed compared with healthy controls and patients with other inflammatory autoimmune diseases. For allelic contrast, except for rs1823375 (P = 0.058) and rs2442598 (P = 0.523), frequencies of alleles for other polymorphisms were significantly different between SLE patients and controls. Genotypes for rs12674822 (TT), rs1868554 (TT, TA and TT+TA), rs734701 (TT) were negatively correlated with SLE susceptibility (OR = 0.564 for rs12674822; OR = 0.572, OR = 0.625, OR = 0.607 for rs1868554; OR = 0.580 for rs734701). Patients carrying rs1868554 T allele and rs3739390 G allele were more likely to develop hematuria (P = 0.039; P = 0.003). The G allele frequencies of rs12674822 and rs2442598 were higher in SLE patients with proteinuria (P = 0.043; P = 0.043). GC genotype frequency of rs3739390 was higher in patients with ds-DNA (+) (P = 0.024). In summary, SLE had increased serum Ang2, which may be a potential biomarker, and the polymorphisms correlated with SLE.
format	article
author	Jia-Min Wang Wang-Dong Xu Zhi-Chao Yuan Qian Wu Jie Zhou An-Fang Huang
author_facet	Jia-Min Wang Wang-Dong Xu Zhi-Chao Yuan Qian Wu Jie Zhou An-Fang Huang
author_sort	Jia-Min Wang
title	Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients
title_short	Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients
title_full	Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients
title_fullStr	Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients
title_full_unstemmed	Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients
title_sort	serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b3fd8e39a18b40d8940e06c931123aac
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Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients

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