Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans

Abstract Insulin increases muscle microvascular perfusion and enhances tissue insulin and nutrient delivery. Our aim was to determine phenotypic traits that foretell human muscle microvascular insulin responses. Hyperinsulinemic euglycemic clamps were performed in 97 adult humans who were lean and h...

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Autores principales:	Kaitlin M. Love, Linda A. Jahn, Lee M. Hartline, James T. Patrie, Eugene J. Barrett, Zhenqi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b4056d7b9f8e47e6b3c79ddc7099260d
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spelling	oai:doaj.org-article:b4056d7b9f8e47e6b3c79ddc7099260d2021-12-02T15:56:56ZInsulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans10.1038/s41598-021-90935-82045-2322https://doaj.org/article/b4056d7b9f8e47e6b3c79ddc7099260d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90935-8https://doaj.org/toc/2045-2322Abstract Insulin increases muscle microvascular perfusion and enhances tissue insulin and nutrient delivery. Our aim was to determine phenotypic traits that foretell human muscle microvascular insulin responses. Hyperinsulinemic euglycemic clamps were performed in 97 adult humans who were lean and healthy, had class 1 obesity without comorbidities, or controlled type 1 diabetes without complications. Insulin-mediated whole-body glucose disposal rates (M-value) and insulin-induced changes in muscle microvascular blood volume (ΔMBV) were determined. Univariate and multivariate analyses were conducted to examine bivariate and multivariate relationships between outcomes, ΔMBV and M-value, and predictor variables, body mass index (BMI), total body weight (WT), percent body fat (BF), lean body mass, blood pressure, maximum consumption of oxygen (VO2max), plasma LDL (LDL-C) and HDL cholesterol, triglycerides (TG), and fasting insulin (INS) levels. Among all factors, only M-value (r = 0.23, p = 0.02) and VO2max (r = 0.20, p = 0.047) correlated with ΔMBV. Conversely, INS (r = − 0.48, p ≤ 0.0001), BF (r = − 0.54, p ≤ 0.001), VO2max (r = 0.5, p ≤ 0.001), BMI (r = − 0.40, p < 0.001), WT (r = − 0.33, p = 0.001), LDL-C (r = − 0.26, p = 0.009), TG (r = − 0.25, p = 0.012) correlated with M-value. While both ΔMBV (p = 0.045) and TG (p = 0.03) provided significant predictive information about M-value in the multivariate regression model, only M-value was uniquely predictive of ΔMBV (p = 0.045). Thus, both M-value and VO2max correlated with ΔMBV but only M-value provided unique predictive information about ΔMBV. This suggests that metabolic and microvascular insulin responses are important predictors of one another, but most metabolic insulin resistance predictors do not predict microvascular insulin responses.Kaitlin M. LoveLinda A. JahnLee M. HartlineJames T. PatrieEugene J. BarrettZhenqi LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaitlin M. Love Linda A. Jahn Lee M. Hartline James T. Patrie Eugene J. Barrett Zhenqi Liu Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
description	Abstract Insulin increases muscle microvascular perfusion and enhances tissue insulin and nutrient delivery. Our aim was to determine phenotypic traits that foretell human muscle microvascular insulin responses. Hyperinsulinemic euglycemic clamps were performed in 97 adult humans who were lean and healthy, had class 1 obesity without comorbidities, or controlled type 1 diabetes without complications. Insulin-mediated whole-body glucose disposal rates (M-value) and insulin-induced changes in muscle microvascular blood volume (ΔMBV) were determined. Univariate and multivariate analyses were conducted to examine bivariate and multivariate relationships between outcomes, ΔMBV and M-value, and predictor variables, body mass index (BMI), total body weight (WT), percent body fat (BF), lean body mass, blood pressure, maximum consumption of oxygen (VO2max), plasma LDL (LDL-C) and HDL cholesterol, triglycerides (TG), and fasting insulin (INS) levels. Among all factors, only M-value (r = 0.23, p = 0.02) and VO2max (r = 0.20, p = 0.047) correlated with ΔMBV. Conversely, INS (r = − 0.48, p ≤ 0.0001), BF (r = − 0.54, p ≤ 0.001), VO2max (r = 0.5, p ≤ 0.001), BMI (r = − 0.40, p < 0.001), WT (r = − 0.33, p = 0.001), LDL-C (r = − 0.26, p = 0.009), TG (r = − 0.25, p = 0.012) correlated with M-value. While both ΔMBV (p = 0.045) and TG (p = 0.03) provided significant predictive information about M-value in the multivariate regression model, only M-value was uniquely predictive of ΔMBV (p = 0.045). Thus, both M-value and VO2max correlated with ΔMBV but only M-value provided unique predictive information about ΔMBV. This suggests that metabolic and microvascular insulin responses are important predictors of one another, but most metabolic insulin resistance predictors do not predict microvascular insulin responses.
format	article
author	Kaitlin M. Love Linda A. Jahn Lee M. Hartline James T. Patrie Eugene J. Barrett Zhenqi Liu
author_facet	Kaitlin M. Love Linda A. Jahn Lee M. Hartline James T. Patrie Eugene J. Barrett Zhenqi Liu
author_sort	Kaitlin M. Love
title	Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
title_short	Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
title_full	Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
title_fullStr	Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
title_full_unstemmed	Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
title_sort	insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b4056d7b9f8e47e6b3c79ddc7099260d
work_keys_str_mv	AT kaitlinmlove insulinmediatedmusclemicrovascularperfusionanditsphenotypicpredictorsinhumans AT lindaajahn insulinmediatedmusclemicrovascularperfusionanditsphenotypicpredictorsinhumans AT leemhartline insulinmediatedmusclemicrovascularperfusionanditsphenotypicpredictorsinhumans AT jamestpatrie insulinmediatedmusclemicrovascularperfusionanditsphenotypicpredictorsinhumans AT eugenejbarrett insulinmediatedmusclemicrovascularperfusionanditsphenotypicpredictorsinhumans AT zhenqiliu insulinmediatedmusclemicrovascularperfusionanditsphenotypicpredictorsinhumans
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Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans

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