Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis
Congenital uterine anomalies (CUA) may influence reproductive performance, resulting in adverse pregnancy associated complications. This study aimed to assess the association of CUA subtypes with reproductive, obstetric, and perinatal outcomes. We performed a systematic search of the MEDLINE, EMBASE...
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MDPI AG
2021
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oai:doaj.org-article:b40779187a784a9bb4cee1353c5be8812021-11-11T17:29:44ZReproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis10.3390/jcm102147972077-0383https://doaj.org/article/b40779187a784a9bb4cee1353c5be8812021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4797https://doaj.org/toc/2077-0383Congenital uterine anomalies (CUA) may influence reproductive performance, resulting in adverse pregnancy associated complications. This study aimed to assess the association of CUA subtypes with reproductive, obstetric, and perinatal outcomes. We performed a systematic search of the MEDLINE, EMBASE, and Cochrane libraries for studies comparing pregnancy outcomes between women with CUA and those with a normal uterus. The random effects model was used to estimate the odds ratios (ORs) with a 95% confidence interval (CI). Women with CUA had a lower rate of live births (OR 0.47; 95% CI 0.33–0.69), and a higher rate of first trimester miscarriage (OR, 1.79; 95% CI 1.34–2.4), second trimester miscarriage (OR 2.92; 95% CI 1.35–6.32), preterm birth (OR 2.98; 95% CI 2.43–3.65), malpresentation (OR 9.1; 95% CI 5.88–14.08), cesarean section (OR 2.87; 95% CI 1.56–5.26), and placental abruption (OR 3.12; 95% CI 1.58–6.18). Women with canalization defects appear to have the poorest reproductive performance during early pregnancy. However, unification defects were associated with obstetric and neonatal outcomes throughout the course of pregnancy. It may be beneficial for clinicians to advise on potential complications that may be increased depending on the type and severity of CUA.Min-A KimHyo Sun KimYoung-Han KimMDPI AGarticlecongenital uterine anomaliesfertilitymiscarriageobstetric outcomeneonatal outcomeMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4797, p 4797 (2021) |
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DOAJ |
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EN |
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congenital uterine anomalies fertility miscarriage obstetric outcome neonatal outcome Medicine R |
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congenital uterine anomalies fertility miscarriage obstetric outcome neonatal outcome Medicine R Min-A Kim Hyo Sun Kim Young-Han Kim Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis |
| description |
Congenital uterine anomalies (CUA) may influence reproductive performance, resulting in adverse pregnancy associated complications. This study aimed to assess the association of CUA subtypes with reproductive, obstetric, and perinatal outcomes. We performed a systematic search of the MEDLINE, EMBASE, and Cochrane libraries for studies comparing pregnancy outcomes between women with CUA and those with a normal uterus. The random effects model was used to estimate the odds ratios (ORs) with a 95% confidence interval (CI). Women with CUA had a lower rate of live births (OR 0.47; 95% CI 0.33–0.69), and a higher rate of first trimester miscarriage (OR, 1.79; 95% CI 1.34–2.4), second trimester miscarriage (OR 2.92; 95% CI 1.35–6.32), preterm birth (OR 2.98; 95% CI 2.43–3.65), malpresentation (OR 9.1; 95% CI 5.88–14.08), cesarean section (OR 2.87; 95% CI 1.56–5.26), and placental abruption (OR 3.12; 95% CI 1.58–6.18). Women with canalization defects appear to have the poorest reproductive performance during early pregnancy. However, unification defects were associated with obstetric and neonatal outcomes throughout the course of pregnancy. It may be beneficial for clinicians to advise on potential complications that may be increased depending on the type and severity of CUA. |
| format |
article |
| author |
Min-A Kim Hyo Sun Kim Young-Han Kim |
| author_facet |
Min-A Kim Hyo Sun Kim Young-Han Kim |
| author_sort |
Min-A Kim |
| title |
Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis |
| title_short |
Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis |
| title_full |
Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis |
| title_fullStr |
Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis |
| title_full_unstemmed |
Reproductive, Obstetric and Neonatal Outcomes in Women with Congenital Uterine Anomalies: A Systematic Review and Meta-Analysis |
| title_sort |
reproductive, obstetric and neonatal outcomes in women with congenital uterine anomalies: a systematic review and meta-analysis |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/b40779187a784a9bb4cee1353c5be881 |
| work_keys_str_mv |
AT minakim reproductiveobstetricandneonataloutcomesinwomenwithcongenitaluterineanomaliesasystematicreviewandmetaanalysis AT hyosunkim reproductiveobstetricandneonataloutcomesinwomenwithcongenitaluterineanomaliesasystematicreviewandmetaanalysis AT younghankim reproductiveobstetricandneonataloutcomesinwomenwithcongenitaluterineanomaliesasystematicreviewandmetaanalysis |
| _version_ |
1718432084813414400 |