C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.

Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs a...

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Autores principales:	Milad Sharifpour, Srikant Rangaraju, Michael Liu, Darwish Alabyad, Fadi B Nahab, Christina M Creel-Bulos, Craig S Jabaley, Emory COVID-19 Quality & Clinical Research Collaborative
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b40d5e49d92e46b9ab4816fe59e00682
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spelling	oai:doaj.org-article:b40d5e49d92e46b9ab4816fe59e006822021-12-02T20:18:57ZC-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.1932-620310.1371/journal.pone.0242400https://doaj.org/article/b40d5e49d92e46b9ab4816fe59e006822020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0242400https://doaj.org/toc/1932-6203Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs across Emory Healthcare System and had at least two CRP values within the first seven days of admission to study the temporal progression of CRP and its association with all-cause in-hospital mortality. The median CRP during hospitalization for the entire cohort was 130 mg/L (IQR 82-191 mg/L), and the median CRP on ICU admission was 169 (IQR 111-234). The hospitalization-wide median CRP was significantly higher amongst the patients who died, compared to those who survived [206 mg/L (157-288 mg/L) vs 114 mg/L (72-160 mg/L), p<0.001]. CRP levels increased in a linear fashion during the first week of hospitalization and peaked on day 5. Compared to patients who died, those who survived had lower peak CRP levels and earlier declines. CRP levels were significantly higher in patients who died compared to those who survived (p<0.001). Our findings support the utility of daily CRP values in hospitalized COVID-19 patients and provide early thresholds during hospitalization that may facilitate risk stratification and prognostication.Milad SharifpourSrikant RangarajuMichael LiuDarwish AlabyadFadi B NahabChristina M Creel-BulosCraig S JabaleyEmory COVID-19 Quality & Clinical Research CollaborativePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 11, p e0242400 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Milad Sharifpour Srikant Rangaraju Michael Liu Darwish Alabyad Fadi B Nahab Christina M Creel-Bulos Craig S Jabaley Emory COVID-19 Quality & Clinical Research Collaborative C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
description	Recent studies have reported that CRP levels are elevated in patients with COVID-19 and may correlate with severity of disease and disease progression. We conducted a retrospective cohort analysis of the medical records of 268 adult patients, who were admitted to one of the six cohorted COVID ICUs across Emory Healthcare System and had at least two CRP values within the first seven days of admission to study the temporal progression of CRP and its association with all-cause in-hospital mortality. The median CRP during hospitalization for the entire cohort was 130 mg/L (IQR 82-191 mg/L), and the median CRP on ICU admission was 169 (IQR 111-234). The hospitalization-wide median CRP was significantly higher amongst the patients who died, compared to those who survived [206 mg/L (157-288 mg/L) vs 114 mg/L (72-160 mg/L), p<0.001]. CRP levels increased in a linear fashion during the first week of hospitalization and peaked on day 5. Compared to patients who died, those who survived had lower peak CRP levels and earlier declines. CRP levels were significantly higher in patients who died compared to those who survived (p<0.001). Our findings support the utility of daily CRP values in hospitalized COVID-19 patients and provide early thresholds during hospitalization that may facilitate risk stratification and prognostication.
format	article
author	Milad Sharifpour Srikant Rangaraju Michael Liu Darwish Alabyad Fadi B Nahab Christina M Creel-Bulos Craig S Jabaley Emory COVID-19 Quality & Clinical Research Collaborative
author_facet	Milad Sharifpour Srikant Rangaraju Michael Liu Darwish Alabyad Fadi B Nahab Christina M Creel-Bulos Craig S Jabaley Emory COVID-19 Quality & Clinical Research Collaborative
author_sort	Milad Sharifpour
title	C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
title_short	C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
title_full	C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
title_fullStr	C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
title_full_unstemmed	C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.
title_sort	c-reactive protein as a prognostic indicator in hospitalized patients with covid-19.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/b40d5e49d92e46b9ab4816fe59e00682
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C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19.

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