Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats

Abstract High-fat diets have been associated with overweight/obesity and increased mortality in middle-aged populations. However, it is still unclear how gut microbiota in middle-aged populations responds to dietary fats at a normal dose. In this study, we explored gut microbiota structure in middle...

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Autores principales:	He Li, Yingying Zhu, Fan Zhao, Shangxin Song, Yingqiu Li, Xinglian Xu, Guanghong Zhou, Chunbao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b40e5f1947c84d0aa78dfa3cdd0abd0e
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spelling	oai:doaj.org-article:b40e5f1947c84d0aa78dfa3cdd0abd0e2021-12-02T12:32:06ZFish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats10.1038/s41598-017-00969-02045-2322https://doaj.org/article/b40e5f1947c84d0aa78dfa3cdd0abd0e2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00969-0https://doaj.org/toc/2045-2322Abstract High-fat diets have been associated with overweight/obesity and increased mortality in middle-aged populations. However, it is still unclear how gut microbiota in middle-aged populations responds to dietary fats at a normal dose. In this study, we explored gut microbiota structure in middle-aged rats (aged 12 months) after feeding 4% (w/w) soybean oil, lard or fish oil for 3 months, respectively. The results showed that the gut microbiota structure in the fish oil group was substantially different from those of the soybean oil and lard groups in both in vitro and in vivo studies. The relative abundances of phylum Proteobacteria and genus Desulfovibrio in the caecal and colonic contents were the highest in the fish oil group (p < 0.05). The mRNA levels of biomarkers for inflammation in the colon, including IL-1β, IL-6, IL-17, IL-18 and TNF-α, were also the highest in the fish oil group (p < 0.05). Meanwhile, the fish oil group had the highest microbial DNA abundance of a predicted lipid metabolism. Our results gave a new insight into the potentially negative impact of fish oil diet on health of middle-aged populations by changing gut microbiota and inducing inflammation as compared to soybean oil and lard diets.He LiYingying ZhuFan ZhaoShangxin SongYingqiu LiXinglian XuGuanghong ZhouChunbao LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q He Li Yingying Zhu Fan Zhao Shangxin Song Yingqiu Li Xinglian Xu Guanghong Zhou Chunbao Li Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
description	Abstract High-fat diets have been associated with overweight/obesity and increased mortality in middle-aged populations. However, it is still unclear how gut microbiota in middle-aged populations responds to dietary fats at a normal dose. In this study, we explored gut microbiota structure in middle-aged rats (aged 12 months) after feeding 4% (w/w) soybean oil, lard or fish oil for 3 months, respectively. The results showed that the gut microbiota structure in the fish oil group was substantially different from those of the soybean oil and lard groups in both in vitro and in vivo studies. The relative abundances of phylum Proteobacteria and genus Desulfovibrio in the caecal and colonic contents were the highest in the fish oil group (p < 0.05). The mRNA levels of biomarkers for inflammation in the colon, including IL-1β, IL-6, IL-17, IL-18 and TNF-α, were also the highest in the fish oil group (p < 0.05). Meanwhile, the fish oil group had the highest microbial DNA abundance of a predicted lipid metabolism. Our results gave a new insight into the potentially negative impact of fish oil diet on health of middle-aged populations by changing gut microbiota and inducing inflammation as compared to soybean oil and lard diets.
format	article
author	He Li Yingying Zhu Fan Zhao Shangxin Song Yingqiu Li Xinglian Xu Guanghong Zhou Chunbao Li
author_facet	He Li Yingying Zhu Fan Zhao Shangxin Song Yingqiu Li Xinglian Xu Guanghong Zhou Chunbao Li
author_sort	He Li
title	Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
title_short	Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
title_full	Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
title_fullStr	Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
title_full_unstemmed	Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
title_sort	fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b40e5f1947c84d0aa78dfa3cdd0abd0e
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Fish oil, lard and soybean oil differentially shape gut microbiota of middle-aged rats

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