Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.

Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3...

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Autores principales:	Huguette Simo Tchetgna, Francine Sado Yousseu, Basile Kamgang, Armel Tedjou, Philip J McCall, Charles S Wondji
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/b40ef5f43e4c492a9f03b25e3720f2b3
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spelling	oai:doaj.org-article:b40ef5f43e4c492a9f03b25e3720f2b32021-12-02T20:23:33ZConcurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.1935-27271935-273510.1371/journal.pntd.0009860https://doaj.org/article/b40ef5f43e4c492a9f03b25e3720f2b32021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009860https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.Huguette Simo TchetgnaFrancine Sado YousseuBasile KamgangArmel TedjouPhilip J McCallCharles S WondjiPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009860 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J McCall Charles S Wondji Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
description	Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.
format	article
author	Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J McCall Charles S Wondji
author_facet	Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J McCall Charles S Wondji
author_sort	Huguette Simo Tchetgna
title	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
title_short	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
title_full	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
title_fullStr	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
title_full_unstemmed	Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
title_sort	concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in cameroon.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b40ef5f43e4c492a9f03b25e3720f2b3
work_keys_str_mv	AT huguettesimotchetgna concurrentcirculationofdengueserotype12and3amongacutefebrilepatientsincameroon AT francinesadoyousseu concurrentcirculationofdengueserotype12and3amongacutefebrilepatientsincameroon AT basilekamgang concurrentcirculationofdengueserotype12and3amongacutefebrilepatientsincameroon AT armeltedjou concurrentcirculationofdengueserotype12and3amongacutefebrilepatientsincameroon AT philipjmccall concurrentcirculationofdengueserotype12and3amongacutefebrilepatientsincameroon AT charlesswondji concurrentcirculationofdengueserotype12and3amongacutefebrilepatientsincameroon
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Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.

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