Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

Here, the authors introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method that considers the heterogeneity of sequenced bulk cells. They apply CHALM to methylation datasets to detect differentially methylated genes that exhibit distinct biological func...

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Autores principales:	Jianfeng Xu, Jiejun Shi, Xiaodong Cui, Ya Cui, Jingyi Jessica Li, Ajay Goel, Xi Chen, Jean-Pierre Issa, Jianzhong Su, Wei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b40f1c110ebc470486f84acea582f1c8
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spelling	oai:doaj.org-article:b40f1c110ebc470486f84acea582f1c82021-12-02T14:01:14ZCellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression10.1038/s41467-020-20492-72041-1723https://doaj.org/article/b40f1c110ebc470486f84acea582f1c82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20492-7https://doaj.org/toc/2041-1723Here, the authors introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method that considers the heterogeneity of sequenced bulk cells. They apply CHALM to methylation datasets to detect differentially methylated genes that exhibit distinct biological functions supporting underlying mechanisms.Jianfeng XuJiejun ShiXiaodong CuiYa CuiJingyi Jessica LiAjay GoelXi ChenJean-Pierre IssaJianzhong SuWei LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianfeng Xu Jiejun Shi Xiaodong Cui Ya Cui Jingyi Jessica Li Ajay Goel Xi Chen Jean-Pierre Issa Jianzhong Su Wei Li Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
description	Here, the authors introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method that considers the heterogeneity of sequenced bulk cells. They apply CHALM to methylation datasets to detect differentially methylated genes that exhibit distinct biological functions supporting underlying mechanisms.
format	article
author	Jianfeng Xu Jiejun Shi Xiaodong Cui Ya Cui Jingyi Jessica Li Ajay Goel Xi Chen Jean-Pierre Issa Jianzhong Su Wei Li
author_facet	Jianfeng Xu Jiejun Shi Xiaodong Cui Ya Cui Jingyi Jessica Li Ajay Goel Xi Chen Jean-Pierre Issa Jianzhong Su Wei Li
author_sort	Jianfeng Xu
title	Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
title_short	Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
title_full	Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
title_fullStr	Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
title_full_unstemmed	Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
title_sort	cellular heterogeneity–adjusted clonal methylation (chalm) improves prediction of gene expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b40f1c110ebc470486f84acea582f1c8
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Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

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