Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

Here, the authors introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method that considers the heterogeneity of sequenced bulk cells. They apply CHALM to methylation datasets to detect differentially methylated genes that exhibit distinct biological func...

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Autores principales: Jianfeng Xu, Jiejun Shi, Xiaodong Cui, Ya Cui, Jingyi Jessica Li, Ajay Goel, Xi Chen, Jean-Pierre Issa, Jianzhong Su, Wei Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/b40f1c110ebc470486f84acea582f1c8
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