Human TRIM gene expression in response to interferons.
<h4>Background</h4>Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antivira...
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2009
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oai:doaj.org-article:b41400da254040758c1fd396562a3da02021-11-25T06:16:39ZHuman TRIM gene expression in response to interferons.1932-620310.1371/journal.pone.0004894https://doaj.org/article/b41400da254040758c1fd396562a3da02009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19290053/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity.<h4>Principal findings</h4>To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcgammaR-mediated activation of macrophages. We found that 27 of the 72 human TRIM genes are sensitive to IFN. Our analysis identifies 9 additional TRIM genes that are up-regulated by IFNs, among which only 3 have previously been found to display an antiviral activity. Also, we found 2 TRIM proteins, TRIM9 and 54, to be specifically up-regulated in FcgammaR-activated macrophages.<h4>Conclusions</h4>Our results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities.Laetitia CarthagenaAnna BergamaschiJoseph M LunaAnnie DavidPradeep D UchilFlorence Margottin-GoguetWalther MothesUriel HazanCatherine TransyGianfranco PancinoSébastien NisolePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 3, p e4894 (2009) |
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Medicine R Science Q Laetitia Carthagena Anna Bergamaschi Joseph M Luna Annie David Pradeep D Uchil Florence Margottin-Goguet Walther Mothes Uriel Hazan Catherine Transy Gianfranco Pancino Sébastien Nisole Human TRIM gene expression in response to interferons. |
| description |
<h4>Background</h4>Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity.<h4>Principal findings</h4>To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcgammaR-mediated activation of macrophages. We found that 27 of the 72 human TRIM genes are sensitive to IFN. Our analysis identifies 9 additional TRIM genes that are up-regulated by IFNs, among which only 3 have previously been found to display an antiviral activity. Also, we found 2 TRIM proteins, TRIM9 and 54, to be specifically up-regulated in FcgammaR-activated macrophages.<h4>Conclusions</h4>Our results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities. |
| format |
article |
| author |
Laetitia Carthagena Anna Bergamaschi Joseph M Luna Annie David Pradeep D Uchil Florence Margottin-Goguet Walther Mothes Uriel Hazan Catherine Transy Gianfranco Pancino Sébastien Nisole |
| author_facet |
Laetitia Carthagena Anna Bergamaschi Joseph M Luna Annie David Pradeep D Uchil Florence Margottin-Goguet Walther Mothes Uriel Hazan Catherine Transy Gianfranco Pancino Sébastien Nisole |
| author_sort |
Laetitia Carthagena |
| title |
Human TRIM gene expression in response to interferons. |
| title_short |
Human TRIM gene expression in response to interferons. |
| title_full |
Human TRIM gene expression in response to interferons. |
| title_fullStr |
Human TRIM gene expression in response to interferons. |
| title_full_unstemmed |
Human TRIM gene expression in response to interferons. |
| title_sort |
human trim gene expression in response to interferons. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2009 |
| url |
https://doaj.org/article/b41400da254040758c1fd396562a3da0 |
| work_keys_str_mv |
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| _version_ |
1718414003700498432 |