Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle

Abstract High taxonomic diversity in non-industrial human gut microbiomes is often interpreted as beneficial; however, it is unclear if taxonomic diversity engenders ecological resilience (i.e. community stability and metabolic continuity). We estimate resilience through genus and species-level rich...

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Autores principales:	David K. Jacobson, Tanvi P. Honap, Andrew T. Ozga, Nicolas Meda, Thérèse S. Kagoné, Hélène Carabin, Paul Spicer, Raul Y. Tito, Alexandra J. Obregon-Tito, Luis Marin Reyes, Luzmila Troncoso-Corzo, Emilio Guija-Poma, Krithivasan Sankaranarayanan, Cecil M. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b416c803469a4b638f9d6798dc65bb18
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spelling	oai:doaj.org-article:b416c803469a4b638f9d6798dc65bb182021-12-02T13:56:48ZAnalysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle10.1038/s41598-021-81257-w2045-2322https://doaj.org/article/b416c803469a4b638f9d6798dc65bb182021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81257-whttps://doaj.org/toc/2045-2322Abstract High taxonomic diversity in non-industrial human gut microbiomes is often interpreted as beneficial; however, it is unclear if taxonomic diversity engenders ecological resilience (i.e. community stability and metabolic continuity). We estimate resilience through genus and species-level richness, phylogenetic diversity, and evenness in short-chain fatty acid (SCFA) production among a global gut metagenome panel of 12 populations (n = 451) representing industrial and non-industrial lifestyles, including novel metagenomic data from Burkina Faso (n = 90). We observe significantly higher genus-level resilience in non-industrial populations, while SCFA production in industrial populations is driven by a few phylogenetically closely related species (belonging to Bacteroides and Clostridium), meaning industrial microbiomes have low resilience potential. Additionally, database bias obfuscates resilience estimates, as we were 2–5 times more likely to identify SCFA-encoding species in industrial microbiomes compared to non-industrial. Overall, we find high phylogenetic diversity, richness, and evenness of bacteria encoding SCFAs in non-industrial gut microbiomes, signaling high potential for resilience in SCFA production, despite database biases that limit metagenomic analysis of non-industrial populations.David K. JacobsonTanvi P. HonapAndrew T. OzgaNicolas MedaThérèse S. KagonéHélène CarabinPaul SpicerRaul Y. TitoAlexandra J. Obregon-TitoLuis Marin ReyesLuzmila Troncoso-CorzoEmilio Guija-PomaKrithivasan SankaranarayananCecil M. LewisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David K. Jacobson Tanvi P. Honap Andrew T. Ozga Nicolas Meda Thérèse S. Kagoné Hélène Carabin Paul Spicer Raul Y. Tito Alexandra J. Obregon-Tito Luis Marin Reyes Luzmila Troncoso-Corzo Emilio Guija-Poma Krithivasan Sankaranarayanan Cecil M. Lewis Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle
description	Abstract High taxonomic diversity in non-industrial human gut microbiomes is often interpreted as beneficial; however, it is unclear if taxonomic diversity engenders ecological resilience (i.e. community stability and metabolic continuity). We estimate resilience through genus and species-level richness, phylogenetic diversity, and evenness in short-chain fatty acid (SCFA) production among a global gut metagenome panel of 12 populations (n = 451) representing industrial and non-industrial lifestyles, including novel metagenomic data from Burkina Faso (n = 90). We observe significantly higher genus-level resilience in non-industrial populations, while SCFA production in industrial populations is driven by a few phylogenetically closely related species (belonging to Bacteroides and Clostridium), meaning industrial microbiomes have low resilience potential. Additionally, database bias obfuscates resilience estimates, as we were 2–5 times more likely to identify SCFA-encoding species in industrial microbiomes compared to non-industrial. Overall, we find high phylogenetic diversity, richness, and evenness of bacteria encoding SCFAs in non-industrial gut microbiomes, signaling high potential for resilience in SCFA production, despite database biases that limit metagenomic analysis of non-industrial populations.
format	article
author	David K. Jacobson Tanvi P. Honap Andrew T. Ozga Nicolas Meda Thérèse S. Kagoné Hélène Carabin Paul Spicer Raul Y. Tito Alexandra J. Obregon-Tito Luis Marin Reyes Luzmila Troncoso-Corzo Emilio Guija-Poma Krithivasan Sankaranarayanan Cecil M. Lewis
author_facet	David K. Jacobson Tanvi P. Honap Andrew T. Ozga Nicolas Meda Thérèse S. Kagoné Hélène Carabin Paul Spicer Raul Y. Tito Alexandra J. Obregon-Tito Luis Marin Reyes Luzmila Troncoso-Corzo Emilio Guija-Poma Krithivasan Sankaranarayanan Cecil M. Lewis
author_sort	David K. Jacobson
title	Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle
title_short	Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle
title_full	Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle
title_fullStr	Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle
title_full_unstemmed	Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle
title_sort	analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b416c803469a4b638f9d6798dc65bb18
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Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle

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