Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance

Serotonin inhibits adipose tissue thermogenesis. Here the authors show that obese mice housed in thermoneutrality have increased mast cell serotonin synthesis, and that inhibiting this pathway through deletion of mast cell Tph1 increases white adipose tissue browning and protects against diet-induce...

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Auteurs principaux:	Julian M. Yabut, Eric M. Desjardins, Eric J. Chan, Emily A. Day, Julie M. Leroux, Bo Wang, Elizabeth D. Crane, Wesley Wong, Katherine M. Morrison, Justin D. Crane, Waliul I. Khan, Gregory R. Steinberg
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b41caca977ab47c4b862d4ee101f56a3
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spelling	oai:doaj.org-article:b41caca977ab47c4b862d4ee101f56a32021-12-02T17:31:08ZGenetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance10.1038/s41467-019-14080-72041-1723https://doaj.org/article/b41caca977ab47c4b862d4ee101f56a32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14080-7https://doaj.org/toc/2041-1723Serotonin inhibits adipose tissue thermogenesis. Here the authors show that obese mice housed in thermoneutrality have increased mast cell serotonin synthesis, and that inhibiting this pathway through deletion of mast cell Tph1 increases white adipose tissue browning and protects against diet-induced obesity, insulin resistance and liver steatosis.Julian M. YabutEric M. DesjardinsEric J. ChanEmily A. DayJulie M. LerouxBo WangElizabeth D. CraneWesley WongKatherine M. MorrisonJustin D. CraneWaliul I. KhanGregory R. SteinbergNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julian M. Yabut Eric M. Desjardins Eric J. Chan Emily A. Day Julie M. Leroux Bo Wang Elizabeth D. Crane Wesley Wong Katherine M. Morrison Justin D. Crane Waliul I. Khan Gregory R. Steinberg Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
description	Serotonin inhibits adipose tissue thermogenesis. Here the authors show that obese mice housed in thermoneutrality have increased mast cell serotonin synthesis, and that inhibiting this pathway through deletion of mast cell Tph1 increases white adipose tissue browning and protects against diet-induced obesity, insulin resistance and liver steatosis.
format	article
author	Julian M. Yabut Eric M. Desjardins Eric J. Chan Emily A. Day Julie M. Leroux Bo Wang Elizabeth D. Crane Wesley Wong Katherine M. Morrison Justin D. Crane Waliul I. Khan Gregory R. Steinberg
author_facet	Julian M. Yabut Eric M. Desjardins Eric J. Chan Emily A. Day Julie M. Leroux Bo Wang Elizabeth D. Crane Wesley Wong Katherine M. Morrison Justin D. Crane Waliul I. Khan Gregory R. Steinberg
author_sort	Julian M. Yabut
title	Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
title_short	Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
title_full	Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
title_fullStr	Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
title_full_unstemmed	Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
title_sort	genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b41caca977ab47c4b862d4ee101f56a3
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Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance

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