Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.

<h4>Background</h4>There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 on the risk of asthma/wheezing among children, which provided suggestive, but inconclusive results.<h4>Methods</h4>To asses...

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Autores principales:	Bing-Fang Hwang, Li-Hao Young, Ching-Hui Tsai, Kuan-Yen Tung, Pei-Chuan Wang, Ming-Wei Su, Yungling Leo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b41e14e5d3fa433f9158851ca69e0a3a
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spelling	oai:doaj.org-article:b41e14e5d3fa433f9158851ca69e0a3a2021-11-18T08:00:16ZFine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.1932-620310.1371/journal.pone.0052715https://doaj.org/article/b41e14e5d3fa433f9158851ca69e0a3a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23357926/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 on the risk of asthma/wheezing among children, which provided suggestive, but inconclusive results.<h4>Methods</h4>To assess the joint effect of air pollutants and GSTP1 on asthma/wheezing, we conducted a nationwide cross-sectional study of 3,825 children in Taiwan Children Health Study. The studied determinants were three GSTP1 Ile105Val (rs 1695) genotypes (Ile-Ile; Ile-Val and Val-Val) and expoure to ambient air pollutants. We used routine air-pollution monitoring data for ozone (O(3)) and particles with an aerodynamic diameter of 2.5 µm or less (PM(2.5)). The effect estimates were presented as odds ratios (ORs) per interquartile changes for PM(2.5) and O(3).<h4>Findings</h4>In a two-stage hierarchical model adjusting for confounding, the risk of asthma was negatively associated with PM(2.5) (adjusted odds ratio (OR) 0.60; 95% confidence interval (CI) 0.45, 0.82) and O(3) (OR 0.74; 95% CI 0.60, 0.90) among Ile105 homozygotes, but positively associated with PM(2.5) (OR 1.52; 95% CI 1.01, 2.27) and O(3) (OR 1.19; 95% CI 0.91, 1.57) among those with at least one val105 allele (interaction p value = 0.001 and 0.03, respectively). A similar tendency of effect modification between PM(2.5) and O(3) and GSTP1 on wheezing was found.<h4>Conclusion</h4>Children who carried Ile105 variant allele and exposed to PM(2.5) and O(3) may be less likely to occurrence of asthma/wheezing.Bing-Fang HwangLi-Hao YoungChing-Hui TsaiKuan-Yen TungPei-Chuan WangMing-Wei SuYungling Leo LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e52715 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bing-Fang Hwang Li-Hao Young Ching-Hui Tsai Kuan-Yen Tung Pei-Chuan Wang Ming-Wei Su Yungling Leo Lee Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.
description	<h4>Background</h4>There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 on the risk of asthma/wheezing among children, which provided suggestive, but inconclusive results.<h4>Methods</h4>To assess the joint effect of air pollutants and GSTP1 on asthma/wheezing, we conducted a nationwide cross-sectional study of 3,825 children in Taiwan Children Health Study. The studied determinants were three GSTP1 Ile105Val (rs 1695) genotypes (Ile-Ile; Ile-Val and Val-Val) and expoure to ambient air pollutants. We used routine air-pollution monitoring data for ozone (O(3)) and particles with an aerodynamic diameter of 2.5 µm or less (PM(2.5)). The effect estimates were presented as odds ratios (ORs) per interquartile changes for PM(2.5) and O(3).<h4>Findings</h4>In a two-stage hierarchical model adjusting for confounding, the risk of asthma was negatively associated with PM(2.5) (adjusted odds ratio (OR) 0.60; 95% confidence interval (CI) 0.45, 0.82) and O(3) (OR 0.74; 95% CI 0.60, 0.90) among Ile105 homozygotes, but positively associated with PM(2.5) (OR 1.52; 95% CI 1.01, 2.27) and O(3) (OR 1.19; 95% CI 0.91, 1.57) among those with at least one val105 allele (interaction p value = 0.001 and 0.03, respectively). A similar tendency of effect modification between PM(2.5) and O(3) and GSTP1 on wheezing was found.<h4>Conclusion</h4>Children who carried Ile105 variant allele and exposed to PM(2.5) and O(3) may be less likely to occurrence of asthma/wheezing.
format	article
author	Bing-Fang Hwang Li-Hao Young Ching-Hui Tsai Kuan-Yen Tung Pei-Chuan Wang Ming-Wei Su Yungling Leo Lee
author_facet	Bing-Fang Hwang Li-Hao Young Ching-Hui Tsai Kuan-Yen Tung Pei-Chuan Wang Ming-Wei Su Yungling Leo Lee
author_sort	Bing-Fang Hwang
title	Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.
title_short	Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.
title_full	Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.
title_fullStr	Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.
title_full_unstemmed	Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.
title_sort	fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione s-transferase p1 polymorphisms.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b41e14e5d3fa433f9158851ca69e0a3a
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Fine particle, ozone exposure, and asthma/wheezing: effect modification by glutathione S-transferase P1 polymorphisms.

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