Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review

BackgroundPeritoneal metastasis (PM) is a late-stage manifestation of intra-abdominal malignancies. The current standard of care indicates that cure can only be achieved with cytoreductive surgery (CRS) which is often indicated with concurrent adjuvant hyperthermic intraperitoneal chemotherapy (HIPE...

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Autores principales:	Daniel Ren Yi Yap, Jolene Si Min Wong, Qiu Xuan Tan, Joey Wee-Shan Tan, Claramae Shulyn Chia, Chin-Ann Johnny Ong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	peritoneal metastasis cytoreductive surgery hyperthermic intraperitoneal chemotherapy (HIPEC) recurrence gastric ovarian Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b41e9e1f99774526abeffa86bbe1eb24
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spelling	oai:doaj.org-article:b41e9e1f99774526abeffa86bbe1eb242021-12-03T05:51:04ZEffect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review2234-943X10.3389/fonc.2021.795390https://doaj.org/article/b41e9e1f99774526abeffa86bbe1eb242021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.795390/fullhttps://doaj.org/toc/2234-943XBackgroundPeritoneal metastasis (PM) is a late-stage manifestation of intra-abdominal malignancies. The current standard of care indicates that cure can only be achieved with cytoreductive surgery (CRS) which is often indicated with concurrent adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC). However, the utility of HIPEC within subsets of PM is not fully understood. We seek to compare the effectiveness of HIPEC in improving peritoneal recurrence rates in PM of different origins.MethodsWe conducted a systematic review of trials on the PubMed, EMBASE, and Cochrane databases, last searched in August 2021. Biases were assessed using the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials as well as the Methodological Index for Non-Randomized Studies (MINORS) framework.Results7 gastric PM studies, 3 ovarian PM studies, and 3 colorectal PM studies were included. Recurrence-free survival was improved in the HIPEC + CRS cohort in 5 gastric trials but only 1 ovarian trial and none of colorectal origin.DiscussionOur findings indicate decent effectiveness of HIPEC in gastric PM, but limited utility in ovarian and colorectal PM. Limitations in the current literature are attributed to the paucity of data available, a lack of homogeneity and consideration of novel and personalised treatment regimens. We implore for further studies to be conducted with a focus on patient selection and stratification, and suggest a reframing of approach towards modern molecular and targeted therapeutic options in future studies of HIPEC.Systematic Review Registrationhttps://www.researchregistry.com/browse-the-registry#registryofsystematicreviewsmeta-analyses/registryofsystematicreviewsmeta-analysesdetails/60c1ffff0c1b78001e8efbe3/, identifier reviewregistry1166.Daniel Ren Yi YapDaniel Ren Yi YapDaniel Ren Yi YapJolene Si Min WongJolene Si Min WongJolene Si Min WongJolene Si Min WongQiu Xuan TanQiu Xuan TanQiu Xuan TanJoey Wee-Shan TanJoey Wee-Shan TanJoey Wee-Shan TanClaramae Shulyn ChiaClaramae Shulyn ChiaClaramae Shulyn ChiaClaramae Shulyn ChiaChin-Ann Johnny OngChin-Ann Johnny OngChin-Ann Johnny OngChin-Ann Johnny OngChin-Ann Johnny OngChin-Ann Johnny OngFrontiers Media S.A.articleperitoneal metastasiscytoreductive surgeryhyperthermic intraperitoneal chemotherapy (HIPEC)recurrencegastricovarianNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	peritoneal metastasis cytoreductive surgery hyperthermic intraperitoneal chemotherapy (HIPEC) recurrence gastric ovarian Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	peritoneal metastasis cytoreductive surgery hyperthermic intraperitoneal chemotherapy (HIPEC) recurrence gastric ovarian Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Daniel Ren Yi Yap Daniel Ren Yi Yap Daniel Ren Yi Yap Jolene Si Min Wong Jolene Si Min Wong Jolene Si Min Wong Jolene Si Min Wong Qiu Xuan Tan Qiu Xuan Tan Qiu Xuan Tan Joey Wee-Shan Tan Joey Wee-Shan Tan Joey Wee-Shan Tan Claramae Shulyn Chia Claramae Shulyn Chia Claramae Shulyn Chia Claramae Shulyn Chia Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review
description	BackgroundPeritoneal metastasis (PM) is a late-stage manifestation of intra-abdominal malignancies. The current standard of care indicates that cure can only be achieved with cytoreductive surgery (CRS) which is often indicated with concurrent adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC). However, the utility of HIPEC within subsets of PM is not fully understood. We seek to compare the effectiveness of HIPEC in improving peritoneal recurrence rates in PM of different origins.MethodsWe conducted a systematic review of trials on the PubMed, EMBASE, and Cochrane databases, last searched in August 2021. Biases were assessed using the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials as well as the Methodological Index for Non-Randomized Studies (MINORS) framework.Results7 gastric PM studies, 3 ovarian PM studies, and 3 colorectal PM studies were included. Recurrence-free survival was improved in the HIPEC + CRS cohort in 5 gastric trials but only 1 ovarian trial and none of colorectal origin.DiscussionOur findings indicate decent effectiveness of HIPEC in gastric PM, but limited utility in ovarian and colorectal PM. Limitations in the current literature are attributed to the paucity of data available, a lack of homogeneity and consideration of novel and personalised treatment regimens. We implore for further studies to be conducted with a focus on patient selection and stratification, and suggest a reframing of approach towards modern molecular and targeted therapeutic options in future studies of HIPEC.Systematic Review Registrationhttps://www.researchregistry.com/browse-the-registry#registryofsystematicreviewsmeta-analyses/registryofsystematicreviewsmeta-analysesdetails/60c1ffff0c1b78001e8efbe3/, identifier reviewregistry1166.
format	article
author	Daniel Ren Yi Yap Daniel Ren Yi Yap Daniel Ren Yi Yap Jolene Si Min Wong Jolene Si Min Wong Jolene Si Min Wong Jolene Si Min Wong Qiu Xuan Tan Qiu Xuan Tan Qiu Xuan Tan Joey Wee-Shan Tan Joey Wee-Shan Tan Joey Wee-Shan Tan Claramae Shulyn Chia Claramae Shulyn Chia Claramae Shulyn Chia Claramae Shulyn Chia Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong
author_facet	Daniel Ren Yi Yap Daniel Ren Yi Yap Daniel Ren Yi Yap Jolene Si Min Wong Jolene Si Min Wong Jolene Si Min Wong Jolene Si Min Wong Qiu Xuan Tan Qiu Xuan Tan Qiu Xuan Tan Joey Wee-Shan Tan Joey Wee-Shan Tan Joey Wee-Shan Tan Claramae Shulyn Chia Claramae Shulyn Chia Claramae Shulyn Chia Claramae Shulyn Chia Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong Chin-Ann Johnny Ong
author_sort	Daniel Ren Yi Yap
title	Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review
title_short	Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review
title_full	Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review
title_fullStr	Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review
title_full_unstemmed	Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review
title_sort	effect of hipec on peritoneal recurrence in peritoneal metastasis treated with cytoreductive surgery: a systematic review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b41e9e1f99774526abeffa86bbe1eb24
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Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review

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