Neutralization mechanism of a highly potent antibody against Zika virus

There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating...

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Autores principales:	Shuijun Zhang, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Ni Lim, Justin S. G. Ooi, Sebastian Lambert, Ter Yong Tan, Douglas G. Widman, Jian Shi, Ralph S. Baric, Shee-Mei Lok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b41f0492a7314c23a5f492f079549fdd
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spelling	oai:doaj.org-article:b41f0492a7314c23a5f492f079549fdd2021-12-02T14:39:32ZNeutralization mechanism of a highly potent antibody against Zika virus10.1038/ncomms136792041-1723https://doaj.org/article/b41f0492a7314c23a5f492f079549fdd2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13679https://doaj.org/toc/2041-1723There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating Zika infections.Shuijun ZhangVictor A. KostyuchenkoThiam-Seng NgXin-Ni LimJustin S. G. OoiSebastian LambertTer Yong TanDouglas G. WidmanJian ShiRalph S. BaricShee-Mei LokNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuijun Zhang Victor A. Kostyuchenko Thiam-Seng Ng Xin-Ni Lim Justin S. G. Ooi Sebastian Lambert Ter Yong Tan Douglas G. Widman Jian Shi Ralph S. Baric Shee-Mei Lok Neutralization mechanism of a highly potent antibody against Zika virus
description	There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating Zika infections.
format	article
author	Shuijun Zhang Victor A. Kostyuchenko Thiam-Seng Ng Xin-Ni Lim Justin S. G. Ooi Sebastian Lambert Ter Yong Tan Douglas G. Widman Jian Shi Ralph S. Baric Shee-Mei Lok
author_facet	Shuijun Zhang Victor A. Kostyuchenko Thiam-Seng Ng Xin-Ni Lim Justin S. G. Ooi Sebastian Lambert Ter Yong Tan Douglas G. Widman Jian Shi Ralph S. Baric Shee-Mei Lok
author_sort	Shuijun Zhang
title	Neutralization mechanism of a highly potent antibody against Zika virus
title_short	Neutralization mechanism of a highly potent antibody against Zika virus
title_full	Neutralization mechanism of a highly potent antibody against Zika virus
title_fullStr	Neutralization mechanism of a highly potent antibody against Zika virus
title_full_unstemmed	Neutralization mechanism of a highly potent antibody against Zika virus
title_sort	neutralization mechanism of a highly potent antibody against zika virus
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b41f0492a7314c23a5f492f079549fdd
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Neutralization mechanism of a highly potent antibody against Zika virus

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