Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes

Anaphylactic reactions during pregnancy can range from subjective cutaneous symptoms to anaphylaxis and lethal anaphylactic shock. The fetal and maternal outcomes are unpredictable. This study is the first systematic review of the clinical presentation of severe anaphylaxis in pregnancy as defined b...

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Autores principales:	Anca Angela Simionescu, Bianca Mihaela Danciu, Ana Maria Alexandra Stanescu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anaphylaxis and pregnancy hypoxic–ischemic encephalopathy adrenaline Medicine R
Acceso en línea:	https://doaj.org/article/b421d12bac7d4230951ae865e7430141
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spelling	oai:doaj.org-article:b421d12bac7d4230951ae865e74301412021-11-25T18:06:48ZSevere Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes10.3390/jpm111110602075-4426https://doaj.org/article/b421d12bac7d4230951ae865e74301412021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1060https://doaj.org/toc/2075-4426Anaphylactic reactions during pregnancy can range from subjective cutaneous symptoms to anaphylaxis and lethal anaphylactic shock. The fetal and maternal outcomes are unpredictable. This study is the first systematic review of the clinical presentation of severe anaphylaxis in pregnancy as defined by the World Allergy Organization to determine maternal and fetal outcomes. We searched PubMed, the Web of Science, and Scopus databases for articles published between 1 January 1985 and 15 April 2021 using the following terms (((anaphylactic shock) AND (pregnancy)) OR ((anaphylaxis) AND (pregnancy))). In 42 studies involving 47 patients, 36.17% of patients were 31–35 years old, and 74.47% of cases occurred peripartum, mostly during cesarean section. Accurate diagnosis with valid and reliable outcome measures was reported for 71.74% of cases. Twenty-two allergens were identified: antibiotics (penicillins and cephalosporins), anesthetic drugs (suxamethonium, mepivacaine), latex, oxytocin, sodium and sucrose iron, laminaria, misoprostol, rubber from Foley catheter, oral phytomenadione, ranitidine, chamomile, and ant sting. Two cases of maternal death related to latex and intravenous iron sucrose, and six infants with neurological disease were reported, mostly related to antibiotics. This review of the currently available literature shows that favorable outcomes are attainable with a high degree of observation, multidisciplinary cooperation, and rapid treatment.Anca Angela SimionescuBianca Mihaela DanciuAna Maria Alexandra StanescuMDPI AGarticleanaphylaxis and pregnancyhypoxic–ischemic encephalopathyadrenalineMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1060, p 1060 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anaphylaxis and pregnancy hypoxic–ischemic encephalopathy adrenaline Medicine R
spellingShingle	anaphylaxis and pregnancy hypoxic–ischemic encephalopathy adrenaline Medicine R Anca Angela Simionescu Bianca Mihaela Danciu Ana Maria Alexandra Stanescu Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes
description	Anaphylactic reactions during pregnancy can range from subjective cutaneous symptoms to anaphylaxis and lethal anaphylactic shock. The fetal and maternal outcomes are unpredictable. This study is the first systematic review of the clinical presentation of severe anaphylaxis in pregnancy as defined by the World Allergy Organization to determine maternal and fetal outcomes. We searched PubMed, the Web of Science, and Scopus databases for articles published between 1 January 1985 and 15 April 2021 using the following terms (((anaphylactic shock) AND (pregnancy)) OR ((anaphylaxis) AND (pregnancy))). In 42 studies involving 47 patients, 36.17% of patients were 31–35 years old, and 74.47% of cases occurred peripartum, mostly during cesarean section. Accurate diagnosis with valid and reliable outcome measures was reported for 71.74% of cases. Twenty-two allergens were identified: antibiotics (penicillins and cephalosporins), anesthetic drugs (suxamethonium, mepivacaine), latex, oxytocin, sodium and sucrose iron, laminaria, misoprostol, rubber from Foley catheter, oral phytomenadione, ranitidine, chamomile, and ant sting. Two cases of maternal death related to latex and intravenous iron sucrose, and six infants with neurological disease were reported, mostly related to antibiotics. This review of the currently available literature shows that favorable outcomes are attainable with a high degree of observation, multidisciplinary cooperation, and rapid treatment.
format	article
author	Anca Angela Simionescu Bianca Mihaela Danciu Ana Maria Alexandra Stanescu
author_facet	Anca Angela Simionescu Bianca Mihaela Danciu Ana Maria Alexandra Stanescu
author_sort	Anca Angela Simionescu
title	Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes
title_short	Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes
title_full	Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes
title_fullStr	Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes
title_full_unstemmed	Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes
title_sort	severe anaphylaxis in pregnancy: a systematic review of clinical presentation to determine outcomes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b421d12bac7d4230951ae865e7430141
work_keys_str_mv	AT ancaangelasimionescu severeanaphylaxisinpregnancyasystematicreviewofclinicalpresentationtodetermineoutcomes AT biancamihaeladanciu severeanaphylaxisinpregnancyasystematicreviewofclinicalpresentationtodetermineoutcomes AT anamariaalexandrastanescu severeanaphylaxisinpregnancyasystematicreviewofclinicalpresentationtodetermineoutcomes
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Severe Anaphylaxis in Pregnancy: A Systematic Review of Clinical Presentation to Determine Outcomes

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