Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Despite functional optimisation during evolution of parasitism, most members of a calcium dependent protein kinase (CDPK) family show genetic redundancy in Plasmodium. Here, the authors screen 294 genetic interactions among protein kinases in Plasmodium and show how some CDPKs functionally interact...

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Autores principales:	Hanwei Fang, Ana Rita Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise M. Walker, Zenon A. Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David A. Baker, Oliver Billker, Mathieu Brochet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b4242e5263e94042a437c38f5c8a5325
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spelling	oai:doaj.org-article:b4242e5263e94042a437c38f5c8a53252021-12-02T15:34:15ZEpistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites10.1038/s41467-018-06733-w2041-1723https://doaj.org/article/b4242e5263e94042a437c38f5c8a53252018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06733-whttps://doaj.org/toc/2041-1723Despite functional optimisation during evolution of parasitism, most members of a calcium dependent protein kinase (CDPK) family show genetic redundancy in Plasmodium. Here, the authors screen 294 genetic interactions among protein kinases in Plasmodium and show how some CDPKs functionally interact to control motility and host cell invasion.Hanwei FangAna Rita GomesNatacha KlagesPaco PinoBohumil MacoEloise M. WalkerZenon A. ZenonosFiona AngrisanoJake BaumChristian DoerigDavid A. BakerOliver BillkerMathieu BrochetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanwei Fang Ana Rita Gomes Natacha Klages Paco Pino Bohumil Maco Eloise M. Walker Zenon A. Zenonos Fiona Angrisano Jake Baum Christian Doerig David A. Baker Oliver Billker Mathieu Brochet Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
description	Despite functional optimisation during evolution of parasitism, most members of a calcium dependent protein kinase (CDPK) family show genetic redundancy in Plasmodium. Here, the authors screen 294 genetic interactions among protein kinases in Plasmodium and show how some CDPKs functionally interact to control motility and host cell invasion.
format	article
author	Hanwei Fang Ana Rita Gomes Natacha Klages Paco Pino Bohumil Maco Eloise M. Walker Zenon A. Zenonos Fiona Angrisano Jake Baum Christian Doerig David A. Baker Oliver Billker Mathieu Brochet
author_facet	Hanwei Fang Ana Rita Gomes Natacha Klages Paco Pino Bohumil Maco Eloise M. Walker Zenon A. Zenonos Fiona Angrisano Jake Baum Christian Doerig David A. Baker Oliver Billker Mathieu Brochet
author_sort	Hanwei Fang
title	Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
title_short	Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
title_full	Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
title_fullStr	Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
title_full_unstemmed	Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
title_sort	epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b4242e5263e94042a437c38f5c8a5325
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Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

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