Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model

ObjectivesTo discriminate viable tumors from benign periablational enhancement (BPE) in early stage after radiofrequency ablation (RFA) is a major confounding problem. The goal of this study is to evaluate quantitative assessment and diagnostic value of CT perfusion between viable tumors and BPE aft...

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Autores principales:	Xiaofei Yue, Xiangjun Dong, Mengting Huang, Hongli Yang, Kun Qian, Changhong Yi, Osamah Alwalid, Yanqiao Ren, Ping Han, Qian Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	radiofrequency ablation HCC computed tomography CT perfusion images VX2 tumor models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b42775d8816f483ab07d5e6fecbcd9d9
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spelling	oai:doaj.org-article:b42775d8816f483ab07d5e6fecbcd9d92021-12-01T01:53:59ZEarly Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model2234-943X10.3389/fonc.2021.728781https://doaj.org/article/b42775d8816f483ab07d5e6fecbcd9d92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.728781/fullhttps://doaj.org/toc/2234-943XObjectivesTo discriminate viable tumors from benign periablational enhancement (BPE) in early stage after radiofrequency ablation (RFA) is a major confounding problem. The goal of this study is to evaluate quantitative assessment and diagnostic value of CT perfusion between viable tumors and BPE after RFA in the rabbit liver VX2 tumor model, with pathological results as the standard.MethodsTwenty-eight VX2 liver tumors were treated with RFA, on days 1, 3, 7, and 14, seven rabbits were randomly chosen for CT perfusion and performed pathology examinations immediately. The perfusion parameters along with the profile of time-density curves (TDCs) and pseudo-color images of the parameters were observed in both BPE and viable tumors, then compared with the pathology results. The perfusion parameters included blood flow (BF), blood volume (BV), time to peak (TTP), permeability (P), arterial liver perfusion (ALP), portal venous perfusion (PVP) and hepatic perfusion index (HPI).ResultsA total of 26/28 rabbits successfully underwent CT perfusion, while 6/26 lesions were confirmed to be viable tumors. The TDCs of BPE were mainly speed-up platform curves (15/26), while the viable tumors showed mainly speed-up speed-down (3/6) and speed-up platform (2/6) curves. The PVP values were significantly higher, and the HPI values were significantly lower for BPE at all time points than viable tumors (P < 0.05). Both of PVP value and HPI value have high efficiency for the differential diagnosis of the viable tumors and BPE at each time point. These characteristics of CT perfusion parameters were consistent with pathological changes.ConclusionsThe TDCs, PVP and HPI have the potential to indicate BPE and viable tumors effectively early after RFA treatment, the results were highly consistent with pathology. CT perfusion has advantages with great efficacy in monitoring the therapeutic effect early after RFA treatment.Xiaofei YueXiaofei YueXiangjun DongXiangjun DongMengting HuangMengting HuangHongli YangHongli YangKun QianKun QianChanghong YiOsamah AlwalidOsamah AlwalidYanqiao RenYanqiao RenPing HanPing HanQian LiQian LiFrontiers Media S.A.articleradiofrequency ablationHCCcomputed tomographyCT perfusion imagesVX2 tumor modelsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiofrequency ablation HCC computed tomography CT perfusion images VX2 tumor models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	radiofrequency ablation HCC computed tomography CT perfusion images VX2 tumor models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiaofei Yue Xiaofei Yue Xiangjun Dong Xiangjun Dong Mengting Huang Mengting Huang Hongli Yang Hongli Yang Kun Qian Kun Qian Changhong Yi Osamah Alwalid Osamah Alwalid Yanqiao Ren Yanqiao Ren Ping Han Ping Han Qian Li Qian Li Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model
description	ObjectivesTo discriminate viable tumors from benign periablational enhancement (BPE) in early stage after radiofrequency ablation (RFA) is a major confounding problem. The goal of this study is to evaluate quantitative assessment and diagnostic value of CT perfusion between viable tumors and BPE after RFA in the rabbit liver VX2 tumor model, with pathological results as the standard.MethodsTwenty-eight VX2 liver tumors were treated with RFA, on days 1, 3, 7, and 14, seven rabbits were randomly chosen for CT perfusion and performed pathology examinations immediately. The perfusion parameters along with the profile of time-density curves (TDCs) and pseudo-color images of the parameters were observed in both BPE and viable tumors, then compared with the pathology results. The perfusion parameters included blood flow (BF), blood volume (BV), time to peak (TTP), permeability (P), arterial liver perfusion (ALP), portal venous perfusion (PVP) and hepatic perfusion index (HPI).ResultsA total of 26/28 rabbits successfully underwent CT perfusion, while 6/26 lesions were confirmed to be viable tumors. The TDCs of BPE were mainly speed-up platform curves (15/26), while the viable tumors showed mainly speed-up speed-down (3/6) and speed-up platform (2/6) curves. The PVP values were significantly higher, and the HPI values were significantly lower for BPE at all time points than viable tumors (P < 0.05). Both of PVP value and HPI value have high efficiency for the differential diagnosis of the viable tumors and BPE at each time point. These characteristics of CT perfusion parameters were consistent with pathological changes.ConclusionsThe TDCs, PVP and HPI have the potential to indicate BPE and viable tumors effectively early after RFA treatment, the results were highly consistent with pathology. CT perfusion has advantages with great efficacy in monitoring the therapeutic effect early after RFA treatment.
format	article
author	Xiaofei Yue Xiaofei Yue Xiangjun Dong Xiangjun Dong Mengting Huang Mengting Huang Hongli Yang Hongli Yang Kun Qian Kun Qian Changhong Yi Osamah Alwalid Osamah Alwalid Yanqiao Ren Yanqiao Ren Ping Han Ping Han Qian Li Qian Li
author_facet	Xiaofei Yue Xiaofei Yue Xiangjun Dong Xiangjun Dong Mengting Huang Mengting Huang Hongli Yang Hongli Yang Kun Qian Kun Qian Changhong Yi Osamah Alwalid Osamah Alwalid Yanqiao Ren Yanqiao Ren Ping Han Ping Han Qian Li Qian Li
author_sort	Xiaofei Yue
title	Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model
title_short	Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model
title_full	Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model
title_fullStr	Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model
title_full_unstemmed	Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model
title_sort	early assessment of response to radiofrequency ablation with ct perfusion imaging in rabbit vx2 liver tumor model
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b42775d8816f483ab07d5e6fecbcd9d9
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Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model

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