Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness

Abstract The purpose is to evaluate the effects of multiple intravitreal ranibizumab (IVR) and aflibercept (IVA) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with exudative age-related macular degeneration (AMD). This retrospective, observational, consecutive ca...

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Main Authors: Jayoung Ahn, Kyuhwan Jang, Joonhong Sohn, Ji In Park, Daniel Duck-Jin Hwang
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Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/b429848b0d70475385de5fd6cc942c0e
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spelling oai:doaj.org-article:b429848b0d70475385de5fd6cc942c0e2021-12-02T13:19:30ZEffect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness10.1038/s41598-021-84648-12045-2322https://doaj.org/article/b429848b0d70475385de5fd6cc942c0e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84648-1https://doaj.org/toc/2045-2322Abstract The purpose is to evaluate the effects of multiple intravitreal ranibizumab (IVR) and aflibercept (IVA) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with exudative age-related macular degeneration (AMD). This retrospective, observational, consecutive case series study enrolled patients newly diagnosed with monocular exudative AMD from January 2014 to October 2019 who were administered IVR or IVA injections. Normal fellow eyes were included as controls. Medical records and spectral domain optical coherence tomography results were reviewed at baseline and at 3, 6, and 12 months after injection. No statistically significant differences in peripapillary RNFL thickness and intraocular pressure were observed between the treated and fellow eyes in the two groups. The global RNFL thicknesses for the treated eyes decreased significantly after 12 months compared with baseline, but no significant difference was observed in any of the six examined sectors (temporal, superior temporal, superior nasal, nasal, inferior nasal, and inferior temporal). At 12 months, the central macular thickness of the treated eyes decreased significantly. Multiple IVR and IVA injections are apparently safe considering peripapillary RNFL damage in patients with exudative AMD. The decreased RNFL thickness of the global sector was presumably due to anatomical improvement of macular lesions.Jayoung AhnKyuhwan JangJoonhong SohnJi In ParkDaniel Duck-Jin HwangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jayoung Ahn
Kyuhwan Jang
Joonhong Sohn
Ji In Park
Daniel Duck-Jin Hwang
Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
description Abstract The purpose is to evaluate the effects of multiple intravitreal ranibizumab (IVR) and aflibercept (IVA) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with exudative age-related macular degeneration (AMD). This retrospective, observational, consecutive case series study enrolled patients newly diagnosed with monocular exudative AMD from January 2014 to October 2019 who were administered IVR or IVA injections. Normal fellow eyes were included as controls. Medical records and spectral domain optical coherence tomography results were reviewed at baseline and at 3, 6, and 12 months after injection. No statistically significant differences in peripapillary RNFL thickness and intraocular pressure were observed between the treated and fellow eyes in the two groups. The global RNFL thicknesses for the treated eyes decreased significantly after 12 months compared with baseline, but no significant difference was observed in any of the six examined sectors (temporal, superior temporal, superior nasal, nasal, inferior nasal, and inferior temporal). At 12 months, the central macular thickness of the treated eyes decreased significantly. Multiple IVR and IVA injections are apparently safe considering peripapillary RNFL damage in patients with exudative AMD. The decreased RNFL thickness of the global sector was presumably due to anatomical improvement of macular lesions.
format article
author Jayoung Ahn
Kyuhwan Jang
Joonhong Sohn
Ji In Park
Daniel Duck-Jin Hwang
author_facet Jayoung Ahn
Kyuhwan Jang
Joonhong Sohn
Ji In Park
Daniel Duck-Jin Hwang
author_sort Jayoung Ahn
title Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_short Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_full Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_fullStr Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_full_unstemmed Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_sort effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b429848b0d70475385de5fd6cc942c0e
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