Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness

Abstract The purpose is to evaluate the effects of multiple intravitreal ranibizumab (IVR) and aflibercept (IVA) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with exudative age-related macular degeneration (AMD). This retrospective, observational, consecutive ca...

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Main Authors:	Jayoung Ahn, Kyuhwan Jang, Joonhong Sohn, Ji In Park, Daniel Duck-Jin Hwang
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/b429848b0d70475385de5fd6cc942c0e
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spelling	oai:doaj.org-article:b429848b0d70475385de5fd6cc942c0e2021-12-02T13:19:30ZEffect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness10.1038/s41598-021-84648-12045-2322https://doaj.org/article/b429848b0d70475385de5fd6cc942c0e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84648-1https://doaj.org/toc/2045-2322Abstract The purpose is to evaluate the effects of multiple intravitreal ranibizumab (IVR) and aflibercept (IVA) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with exudative age-related macular degeneration (AMD). This retrospective, observational, consecutive case series study enrolled patients newly diagnosed with monocular exudative AMD from January 2014 to October 2019 who were administered IVR or IVA injections. Normal fellow eyes were included as controls. Medical records and spectral domain optical coherence tomography results were reviewed at baseline and at 3, 6, and 12 months after injection. No statistically significant differences in peripapillary RNFL thickness and intraocular pressure were observed between the treated and fellow eyes in the two groups. The global RNFL thicknesses for the treated eyes decreased significantly after 12 months compared with baseline, but no significant difference was observed in any of the six examined sectors (temporal, superior temporal, superior nasal, nasal, inferior nasal, and inferior temporal). At 12 months, the central macular thickness of the treated eyes decreased significantly. Multiple IVR and IVA injections are apparently safe considering peripapillary RNFL damage in patients with exudative AMD. The decreased RNFL thickness of the global sector was presumably due to anatomical improvement of macular lesions.Jayoung AhnKyuhwan JangJoonhong SohnJi In ParkDaniel Duck-Jin HwangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jayoung Ahn Kyuhwan Jang Joonhong Sohn Ji In Park Daniel Duck-Jin Hwang Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
description	Abstract The purpose is to evaluate the effects of multiple intravitreal ranibizumab (IVR) and aflibercept (IVA) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with exudative age-related macular degeneration (AMD). This retrospective, observational, consecutive case series study enrolled patients newly diagnosed with monocular exudative AMD from January 2014 to October 2019 who were administered IVR or IVA injections. Normal fellow eyes were included as controls. Medical records and spectral domain optical coherence tomography results were reviewed at baseline and at 3, 6, and 12 months after injection. No statistically significant differences in peripapillary RNFL thickness and intraocular pressure were observed between the treated and fellow eyes in the two groups. The global RNFL thicknesses for the treated eyes decreased significantly after 12 months compared with baseline, but no significant difference was observed in any of the six examined sectors (temporal, superior temporal, superior nasal, nasal, inferior nasal, and inferior temporal). At 12 months, the central macular thickness of the treated eyes decreased significantly. Multiple IVR and IVA injections are apparently safe considering peripapillary RNFL damage in patients with exudative AMD. The decreased RNFL thickness of the global sector was presumably due to anatomical improvement of macular lesions.
format	article
author	Jayoung Ahn Kyuhwan Jang Joonhong Sohn Ji In Park Daniel Duck-Jin Hwang
author_facet	Jayoung Ahn Kyuhwan Jang Joonhong Sohn Ji In Park Daniel Duck-Jin Hwang
author_sort	Jayoung Ahn
title	Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_short	Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_full	Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_fullStr	Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_full_unstemmed	Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
title_sort	effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b429848b0d70475385de5fd6cc942c0e
work_keys_str_mv	AT jayoungahn effectofintravitrealranibizumabandafliberceptinjectionsonretinalnervefiberlayerthickness AT kyuhwanjang effectofintravitrealranibizumabandafliberceptinjectionsonretinalnervefiberlayerthickness AT joonhongsohn effectofintravitrealranibizumabandafliberceptinjectionsonretinalnervefiberlayerthickness AT jiinpark effectofintravitrealranibizumabandafliberceptinjectionsonretinalnervefiberlayerthickness AT danielduckjinhwang effectofintravitrealranibizumabandafliberceptinjectionsonretinalnervefiberlayerthickness
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Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness

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