Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Single-cell RNA-seq offers the opportunity to improve efficacy of T-cell based immunotherapy. Here the authors develop a plate-based method for cytotoxic T cell profiling. It captures a higher number of transcripts and detects gene with increased dynamic range in comparison to droplet-based methods.

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Autores principales:	Kristiyan Kanev, Patrick Roelli, Ming Wu, Christine Wurmser, Mauro Delorenzi, Michael W. Pfaffl, Dietmar Zehn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b42989778967480ba4038ed5f8239c85
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spelling	oai:doaj.org-article:b42989778967480ba4038ed5f8239c852021-12-02T13:57:31ZTailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells10.1038/s41467-020-20751-72041-1723https://doaj.org/article/b42989778967480ba4038ed5f8239c852021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20751-7https://doaj.org/toc/2041-1723Single-cell RNA-seq offers the opportunity to improve efficacy of T-cell based immunotherapy. Here the authors develop a plate-based method for cytotoxic T cell profiling. It captures a higher number of transcripts and detects gene with increased dynamic range in comparison to droplet-based methods.Kristiyan KanevPatrick RoelliMing WuChristine WurmserMauro DelorenziMichael W. PfafflDietmar ZehnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristiyan Kanev Patrick Roelli Ming Wu Christine Wurmser Mauro Delorenzi Michael W. Pfaffl Dietmar Zehn Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells
description	Single-cell RNA-seq offers the opportunity to improve efficacy of T-cell based immunotherapy. Here the authors develop a plate-based method for cytotoxic T cell profiling. It captures a higher number of transcripts and detects gene with increased dynamic range in comparison to droplet-based methods.
format	article
author	Kristiyan Kanev Patrick Roelli Ming Wu Christine Wurmser Mauro Delorenzi Michael W. Pfaffl Dietmar Zehn
author_facet	Kristiyan Kanev Patrick Roelli Ming Wu Christine Wurmser Mauro Delorenzi Michael W. Pfaffl Dietmar Zehn
author_sort	Kristiyan Kanev
title	Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells
title_short	Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells
title_full	Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells
title_fullStr	Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells
title_full_unstemmed	Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells
title_sort	tailoring the resolution of single-cell rna sequencing for primary cytotoxic t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b42989778967480ba4038ed5f8239c85
work_keys_str_mv	AT kristiyankanev tailoringtheresolutionofsinglecellrnasequencingforprimarycytotoxictcells AT patrickroelli tailoringtheresolutionofsinglecellrnasequencingforprimarycytotoxictcells AT mingwu tailoringtheresolutionofsinglecellrnasequencingforprimarycytotoxictcells AT christinewurmser tailoringtheresolutionofsinglecellrnasequencingforprimarycytotoxictcells AT maurodelorenzi tailoringtheresolutionofsinglecellrnasequencingforprimarycytotoxictcells AT michaelwpfaffl tailoringtheresolutionofsinglecellrnasequencingforprimarycytotoxictcells AT dietmarzehn tailoringtheresolutionofsinglecellrnasequencingforprimarycytotoxictcells
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Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

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