Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level

Abstract In scaling up an ultra-rapid genomics program, we used implementation science principles to design and investigate influences on implementation and identify strategies required for sustainable “real-world” services. Interviews with key professionals revealed the importance of networks and r...

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Autores principales:	Stephanie Best, Helen Brown, Sebastian Lunke, Chirag Patel, Jason Pinner, Christopher P. Barnett, Meredith Wilson, Sarah A. Sandaradura, Belinda McClaren, Gemma R. Brett, Jeffrey Braithwaite, Zornitza Stark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/b42ddf71ebe64c6cb39c4da2f06993e1
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spelling	oai:doaj.org-article:b42ddf71ebe64c6cb39c4da2f06993e12021-12-02T14:16:42ZLearning from scaling up ultra-rapid genomic testing for critically ill children to a national level10.1038/s41525-020-00168-32056-7944https://doaj.org/article/b42ddf71ebe64c6cb39c4da2f06993e12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41525-020-00168-3https://doaj.org/toc/2056-7944Abstract In scaling up an ultra-rapid genomics program, we used implementation science principles to design and investigate influences on implementation and identify strategies required for sustainable “real-world” services. Interviews with key professionals revealed the importance of networks and relationship building, leadership, culture, and the relative advantage afforded by ultra-rapid genomics in the care of critically ill children. Although clinical geneticists focused on intervention characteristics and the fit with patient-centered care, intensivists emphasized the importance of access to knowledge, in particular from clinical geneticists. The relative advantage of ultra-rapid genomics and trust in consistent and transparent delivery were significant in creating engagement at initial implementation, with appropriate resourcing highlighted as important for longer term sustainability of implementation. Our findings demonstrate where common approaches can be used and, significantly, where there is a need to tailor support by professional role and implementation phase, to maximize the potential of ultra-rapid genomic testing to improve patient care.Stephanie BestHelen BrownSebastian LunkeChirag PatelJason PinnerChristopher P. BarnettMeredith WilsonSarah A. SandaraduraBelinda McClarenGemma R. BrettJeffrey BraithwaiteZornitza StarkNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Stephanie Best Helen Brown Sebastian Lunke Chirag Patel Jason Pinner Christopher P. Barnett Meredith Wilson Sarah A. Sandaradura Belinda McClaren Gemma R. Brett Jeffrey Braithwaite Zornitza Stark Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
description	Abstract In scaling up an ultra-rapid genomics program, we used implementation science principles to design and investigate influences on implementation and identify strategies required for sustainable “real-world” services. Interviews with key professionals revealed the importance of networks and relationship building, leadership, culture, and the relative advantage afforded by ultra-rapid genomics in the care of critically ill children. Although clinical geneticists focused on intervention characteristics and the fit with patient-centered care, intensivists emphasized the importance of access to knowledge, in particular from clinical geneticists. The relative advantage of ultra-rapid genomics and trust in consistent and transparent delivery were significant in creating engagement at initial implementation, with appropriate resourcing highlighted as important for longer term sustainability of implementation. Our findings demonstrate where common approaches can be used and, significantly, where there is a need to tailor support by professional role and implementation phase, to maximize the potential of ultra-rapid genomic testing to improve patient care.
format	article
author	Stephanie Best Helen Brown Sebastian Lunke Chirag Patel Jason Pinner Christopher P. Barnett Meredith Wilson Sarah A. Sandaradura Belinda McClaren Gemma R. Brett Jeffrey Braithwaite Zornitza Stark
author_facet	Stephanie Best Helen Brown Sebastian Lunke Chirag Patel Jason Pinner Christopher P. Barnett Meredith Wilson Sarah A. Sandaradura Belinda McClaren Gemma R. Brett Jeffrey Braithwaite Zornitza Stark
author_sort	Stephanie Best
title	Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
title_short	Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
title_full	Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
title_fullStr	Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
title_full_unstemmed	Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
title_sort	learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b42ddf71ebe64c6cb39c4da2f06993e1
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Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level

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